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  • Influence
Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis.
Wnt signalling plays a crucial role in the control of morphogenetic movements. We describe the expression and functional analyses of frizzled 7 (Xfz7) during gastrulation in Xenopus. Low levels ofExpand
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Connecting the Navigational Clock to Sun Compass Input in Monarch Butterfly Brain
Migratory monarch butterflies (Danaus plexippus) use a time-compensated sun compass to navigate to their overwintering grounds in Mexico. Although polarized light is one of the celestial cues usedExpand
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Regulation of the MDM2-p53 Pathway by Ribosomal Protein L11 Involves a Post-ubiquitination Mechanism*
  • M. Dai, D. Shi, +4 authors H. Lu
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 25 August 2006
Inhibition of the MDM2-p53 feedback loop is critical for p53 activation in response to cellular stresses. The ribosomal proteins L5, L11, and L23 can block this loop by inhibiting MDM2-mediated p53Expand
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Dual Roles of MDM2 in the Regulation of p53: Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity.
  • D. Shi, W. Gu
  • Medicine, Biology
  • Genes & cancer
  • 1 March 2012
MDM2 oncogenic protein is the principal cellular antagonist of the p53 tumor suppresser gene. p53 activity needs exquisite control to elicit appropriate responses to differential cellular stressExpand
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The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3
The activity of p53 as a tumor suppressor primarily depends on its ability to transactivate specific target genes in response to genotoxic and other potentially mutagenic stresses. Several histoneExpand
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Ubiquitin becomes ubiquitous in cancer
By virtue of its ability to regulate both protein turnover and non-proteolytic signalling functions, ubiquitin protein conjugation has been implicated in the control of multiple cellular processes,Expand
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Negative regulation of the p300-p53 interplay by DDX24
Numerous studies indicate that p300 acts as a key transcriptional cofactor in vivo, at least, in part, by modulating activities of p53 by acetylation. Nevertheless, the regulation of the p53-p300Expand
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Negative Regulation of the Acetyltransferase TIP60-p53 Interplay by UHRF1 (Ubiquitin-like with PHD and RING Finger Domains 1)*
Background: The TIP60 acetyltransferase mediates p53 acetylation at K120 and is required for p53-dependent growth arrest and apoptosis. Results: UHRF1 suppresses TIP60 interaction with p53 andExpand
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p53 Ubiquitination and proteasomal degradation.
p53 levels and activity are controlled in large part through regulated ubiquitination and subsequent destruction by the 26S proteasome. Monoubiquitination of p53 is mediated primarily by theExpand
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Correction for Manríquez et al., Adaptive shell color plasticity during the early ontogeny of an intertidal keystone snail
Correction for ‘‘The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds,’’ by Hae Joo Kang, Neil G. Paterson, Andrew H.Expand
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