• Publications
  • Influence
Consensus Guidelines for Managing Postoperative Nausea and Vomiting
Evidence-based guidelines developed by an international panel of experts for the management of postoperative nausea and vomiting are presented. Expand
A factorial trial of six interventions for the prevention of postoperative nausea and vomiting.
Ondansetron, dexamethasone, and droperidol each reduced the risk of postoperative nausea and vomiting by about 26 percent, and the safest or least expensive antiemetic interventions should be used first. Expand
Remifentanil-induced Postoperative Hyperalgesia and Its Prevention with Small-dose Ketamine
A relatively large dose of intraoperative remifentanil triggers postoperative secondary hyperalgesia and is prevented by small-dose ketamine, implicating an N-methyl-d-aspartate pain-facilitator process. Expand
Duration of red-cell storage and complications after cardiac surgery.
In patients undergoing cardiac surgery, transfusion of red cells that had been stored for more than 2 weeks was associated with a significantly increased risk of postoperative complications as well as reduced short-term and long-term survival. Expand
Temperature Monitoring and Perioperative Thermoregulation
Most clinically available thermometers accurately report the temperature of whatever tissue is being measured. The difficulty is that no reliably core-temperature-measuring sites are completelyExpand
Opioid-induced bowel dysfunction: pathophysiology and potential new therapies.
Current management of opioid-induced bowel dysfunction among patients receiving opioid analgesics consists primarily of nonspecific ameliorative measures and recent clinical studies with alvimopan suggest that it may normalise bowel function without blocking opioid analgesia in abdominal laparotomy patients with opioid-related postoperative ileus. Expand
Perioperative heat balance.
Mechanisms indicate that alterations in the distribution of body heat contribute more to changes in core temperature than to systemic heat imbalance in most patients. Expand
Relationship between Intraoperative Mean Arterial Pressure and Clinical Outcomes after Noncardiac Surgery: Toward an Empirical Definition of Hypotension
Even short durations of an intraoperative mean arterial pressure less than 55 mmHg are associated with AKI and myocardial injury, and Randomized trials are required to determine whether outcomes improve with interventions that maintain an intraoper MAP of at least 55mmHg. Expand
Myocardial Injury after Noncardiac Surgery: A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes
Among adults undergoing noncardiac surgery, MINS was an independent predictor of 30-day mortality and had the highest population-attributable risk of the perioperative complications. Expand
Mild perioperative hypothermia.
  • D. Sessler
  • Medicine
  • The New England journal of medicine
  • 12 June 1997
The human thermoregulatory system usually maintains a core body temperature near 37°C, but perioperative hypothermia, however, is common because of the inhibition of thermoreGulation induced by anesthesia and the patient's exposure to a cool environment. Expand