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An in vitro spectroscopic analysis to determine whether para-chloroaniline is produced from mixing sodium hypochlorite and chlorhexidine.
INTRODUCTION The purpose of this in vitro study was to determine whether para-chloroaniline (PCA) is formed through the reaction of mixing sodium hypochlorite (NaOCl) and chlorhexidine (CHX). … Expand
Nmr in drug discovery
NMR spectroscopy has evolved into an important technique in support of structure-based drug design. Here, we survey the principles that enable NMR to provide information on the nature of molecular… Expand
An in vitro spectroscopic analysis to determine the chemical composition of the precipitate formed by mixing sodium hypochlorite and chlorhexidine.
INTRODUCTION The purpose of this in vitro study was to determine the chemical composition of the precipitate formed by mixing sodium hypochlorite (NaOCl) and chlorhexidine (CHX) and the relative… Expand
Conserved amino acids in each subunit of the heteroligomeric tRNA m1A58 Mtase from Saccharomyces cerevisiae contribute to tRNA binding
- Sarah G. Ozanick, J. Bujnicki, D. Sem, JamesC . Anderson
- Biology, Medicine
- Nucleic acids research
- 10 October 2007
In Saccharomyces cerevisiae, a two-subunit methyltransferase (Mtase) encoded by the essential genes TRM6 and TRM61 is responsible for the formation of 1-methyladenosine, a modified nucleoside found… Expand
NMR-based structural characterization of large protein-ligand interactions
- M. Pellecchia, D. Meininger, Qing Dong, Edcon Chang, R. Jack, D. Sem
- Medicine, Chemistry
- Journal of biomolecular NMR
- 1 February 2002
Genomic research on target identification and validation has created a great need for methods that rapidly provide detailed structural information on protein-ligand interactions. We developed a suite… Expand
Mechanistic Studies on the Reductive Half-reaction of NADPH-Cytochrome P450 Oxidoreductase*
Site-directed mutagenesis has been employed to study the mechanism of hydride transfer from NADPH to NADPH-cytochrome P450 oxidoreductase. Specifically, Ser457, Asp675, and Cys630 have been selected… Expand
High-resolution solution structure of the retinoid X receptor DNA-binding domain.
- S. Holmbeck, M. Foster, D. Casimiro, D. Sem, H. Dyson, P. Wright
- Chemistry, Medicine
- Journal of molecular biology
- 14 August 1998
The retinoid X receptor (RXR) is a member of the nuclear hormone receptor superfamily of transcriptional regulators and plays a central role in the retinoid and, through its ability to heterodimerize… Expand
Intracellular DNA strand scission and growth inhibition of Ehrlich ascites tumor cells by bleomycins.
- R. Byrnes, J. Templin, D. Sem, S. Lyman, D. Petering
- Biology, Medicine
- Cancer research
- 1 September 1990
A comparison of the intracellular DNA strand scission activities of the antitumor drug bleomycin, three of its metal complexes, demethyl bleomycin A2, and iron-containing, redox-inactivated bleomycin… Expand
Fluorescence-based detection of thiols in vitro and in vivo using dithiol probes.
Thiols play a central role in maintaining biological homeostasis. Their levels can change dramatically in response to oxidative stress associated with toxic insults, bacterial infection, and disease.… Expand
Effect of ionic strength on the kinetic mechanism and relative rate limitation of steps in the model NADPH-cytochrome P450 oxidoreductase reaction with cytochrome c.
Although the kinetic mechanism of the NADPH-cytochrome P450 oxidoreductase (P450R) reaction with cytochrome c3+ has been determined at 850 mM ionic strength [Sem, D.S., & Kasper, C. B. (1994)… Expand