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HIV-1 evades innate immune recognition through specific co-factor recruitment
TLDR
It is concluded that HIV-1 has evolved to use CPSF6 and cyclophilins to cloak its replication, allowing evasion of innate immune sensors and induction of a cell-autonomous innate immune response in primary human macrophages. Expand
Disruption of methylarginine metabolism impairs vascular homeostasis
TLDR
It is shown that loss of DDAH-1 activity leads to accumulation of ADMA and reduction in NO signaling, which causes vascular pathophysiology, including endothelial dysfunction, increased systemic vascular resistance and elevated systemic and pulmonary blood pressure, and it is suggested that DDAh inhibition could be harnessed therapeutically to reduce the vascular collapse associated with sepsis. Expand
Endothelial C-type natriuretic peptide maintains vascular homeostasis.
TLDR
This work provides a mechanistic explanation for genome-wide association studies that have linked the NPR-C (Npr3) locus with hypertension by demonstrating the importance of CNP/NPR-C signaling in preserving vascular homoeostasis and suggesting that the CNP-C pathway has potential as a disease-modifying therapeutic target for cardiovascular disorders. Expand
Characterization of a Bicyclic Peptide Neuropilin-1 (NP-1) Antagonist (EG3287) Reveals Importance of Vascular Endothelial Growth Factor Exon 8 for NP-1 Binding and Role of NP-1 in KDR Signaling*
TLDR
It is demonstrated that NP-1 is essential for optimum KDR activation and intracellular signaling and the results identify a key role for the C-terminal exon 8 domain in VEGF-A165 binding toNP-1. Expand
Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity
TLDR
These findings indicate that NRP1 is important for tumour cell migration and adhesion, and that N RP1 antagonism enhances chemosensitivity, at least in part, by interfering with integrin-dependent survival pathways. Expand
Cysteine-rich and basic domain HIV-1 Tat peptides inhibit angiogenesis and induce endothelial cell apoptosis.
TLDR
It is found that both cysteine-rich and basic domain Tat peptides strikingly induced apoptosis in endothelial cells, independent of their effects on VEGF and bFGF. Expand
Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids
TLDR
It is shown that synthetic cannabidiol can slow down the accumulation of disability from the inflammatory penumbra during relapsing experimental autoimmune encephalomyelitis (EAE) in ABH mice, possibly via blockade of voltage-gated sodium channels. Expand
Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation
TLDR
It is concluded that CyP-D has a major pathogenic role in ‘energy failure’, but not in glutamate excitotoxicity, where cytoprotection primarily reflects CsA interaction with extramitochondrial CyPs and calcineurin. Expand
Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase.
TLDR
In vivo administration of substrate-based inhibitors of mammalian DDAH increases plasma ADMA levels, giving proof of concept that these inhibitors can be used to probe the physiological effects of DDAh inhibition, with potential for pharmaceutical use of D DAH inhibitors in diseases where excess NO production is implicated. Expand
Anti-chemorepulsive Effects of Vascular Endothelial Growth Factor and Placental Growth Factor-2 in Dorsal Root Ganglion Neurons Are Mediated via Neuropilin-1 and Cyclooxygenase-derived Prostanoid
TLDR
Findings support a specific role for NP-1 in mediating neurotrophic actions of VEGF family members and also identify a novel role for prostanoids in the inhibition of neuronal chemorepulsion. Expand
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