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The Continuing Challenges of Leprosy
This review focuses on recent advances in the understanding of M. leprae and the host response to it, especially concerning molecular identification of M.'s genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis. Expand
Probable zoonotic leprosy in the southern United States.
Wild armadillos and many patients with leprosy in the southern United States are infected with the same strain of M. leprae, andLeprosy may be a zoonosis in the region. Expand
The biology of nerve injury in leprosy.
The results of all of these studies can be reasonably expected to identify new points for clinical intervention in--and possibly the prevention of--nerve injury in leprosy. Expand
Potential plasma markers of type 1 and type 2 leprosy reactions: a preliminary report
Potential biomarkers of T1R identified were CXCL10 and IL 6 whereas IL7, PDGF-BB and IL6, may be laboratory markers of TR2, and additional studies on these biomarkers may help understand the immunopathologic mechanisms of leprosy reactions. Expand
Development of leprosy and type 1 leprosy reactions after treatment with infliximab: a report of 2 cases.
The first 2 cases of leprosy developing after treatment with infliximab are reported, and both patients developed type 1 ("reversal") leproSy reactions. Expand
Methods for the classification of leprosy for treatment purposes.
The World Health Organization advocates 2 leprosy treatment regimens on the basis of disease classification (as multibacillary or paucibACillary) by skin lesion count, and classification using standard histopathological and microbiological criteria in 264 currently untreated patients withLeprosy resulted in a high prevalence of this method in the Philippines. Expand
Molecular Determination of Mycobacterium leprae Viability by Use of Real-Time PCR
Two quantitative reverse transcriptase PCR assays were developed and characterized and consistently identified the presence of M. leprae in eight multibacillary leprosy patient biopsy specimens prior to multidrug therapy (MDT) and demonstrated a decline in viability during the course of MDT. Expand
Epidemiologic characteristics of leprosy reactions.
An 8-year prospective study of a cohort of 176 newly diagnosed leprosy patients was conducted to examine the possible influence of age, sex, multidrug therapy (MDT), and duration of illness on theExpand
Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009–15
This is the first study reporting global data on AMR in leprosy, and rifampicin resistance emerged, stressing the need for expansion of surveillance and call for vigilance on the global use of antimicrobial agents. Expand
Compound Heterozygous CORO1A Mutations in Siblings with a Mucocutaneous-Immunodeficiency Syndrome of Epidermodysplasia Verruciformis-HPV, Molluscum Contagiosum and Granulomatous Tuberculoid Leprosy
A 10-year analysis of the immune-clinical phenotypes in two affected siblings from disease debut of age 7 years reveals the third CORO1A-mutated kindred, with the immune phenotype of abnormal naïve CD4 and DN T-cells and newfound characteristics of a late/hypomorphic-like SCID of an EV-HPV mucocutaneous syndrome. Expand