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In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency
It is suggested that because of viral cytopathic effects and/or host effector mechanisms, productively infected CD4+ T cells do not generally survive for long enough to revert to a resting memory state in vivo. Expand
Actin-Dependent Receptor Colocalization Required for Human Immunodeficiency Virus Entry into Host Cells
HIV entry required actin-dependent concentration of coreceptors, which could be disrupted by cytochalasin D (CytoD) without an effect on cell viability or mitosis, but pretreatment of peripheral blood mononuclear cells, but not virus, inhibited entry and infection. Expand
Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1. The National Institute
There is a qualitative, or large quantitative, difference in the neutralizing antibody response induced by envelope subunit vaccination and natural HIV-1 infection, which is more susceptible to neutralization than are primary isolates cultured in human peripheral blood mononuclear cells. Expand
Defective accessory genes in a human immunodeficiency virus type 1-infected long-term survivor lacking recoverable virus.
The results of an intensive molecular genetic analysis of the HIV-1 proviral quasispecies from this patient sampled over 5 years suggest that this patient is presently infected with a more-attenuated viral quasipecies as a result of effective host immunity. Expand
Advancing AIDSVAX to phase 3. Safety, immunogenicity, and plans for phase 3.
AIDSVAX (VaxGen, Inc., South San Francisco, CA), a possible vaccine to protect against human immunodeficiency virus type 1 (HIV-1) infection, is being tested for efficacy in phase 3 studies. It hasExpand
Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India
Among asymptomatic individuals in this cohort, a dramatic increase in plasma interleukin (IL)-10 coincided with rapid decrease in CD4 counts and progression to AIDS, which is in agreement with an earlier report of rapid progression in India. Expand
Molecular Confirmation of Human Immunodeficiency Virus (HIV) Type 2 in HIV-Seropositive Subjects in South India
The prevalence of HIV-2 is accurately estimated by the use of immunoblotting, but that of HIV -1 and -2 dual infection may be overestimated. Expand
Safety and immunogenicity of a candidate HIV-1 vaccine in healthy adults: recombinant glycoprotein (rgp) 120. A randomized, double-blind trial. NIAID AIDS Vaccine Evaluation Group.
The SF-2 rgp120 vaccine is safe and immunogenic, and type-specific and crossreactive neutralizing antibody responses against B-subtype laboratory strains of HIV-1 and CD8+ cytotoxic T-lymphocyte activity was detected in 11 participants tested. Expand
QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immunization in humans.
The use of QS-21 may provide a means to reduce the dose of a soluble protein immunogen by improving the magnitude or kinetics of immune responses induced by recombinant soluble gp120 HIV-1(MN) protein immunization. Expand
Anatomical loci of HIV-associated immune activation and association with viraemia
BACKGROUND Lymphocyte activation, associated with vaccination or infection, can be measured by positron emission tomography (PET). We investigated the ability of PET to detect and measure magnitudeExpand