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Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis.
TLDR
The determination of differences in hind paw weight distribution in the rat MIA model of OA is a technically straightforward, reproducible method that is predictive of the effects of anti-inflammatory and analgesic agents and useful for the discovery of novel pharmacologic agents in human OA. Expand
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
TLDR
A subpopulation of adipogenic progenitors residing in murine brown fat, white fat, and skeletal muscle is identified and a dynamic interplay between these progenitor cells and inductive signals that act in concert to specify brown adipocyte development is demonstrated. Expand
Expression of lung vascular and airway ICAM-1 after exposure to bacterial lipopolysaccharide.
TLDR
Data indicate, at the very least, a dual compartmentalized (vascular and airway) upregulation of ICAM-1 after airway instillation of LPS, which requires TNF-alpha and IL-1. Expand
Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms.
TLDR
The inhibition of murine CIA by PD184352 is demonstrated, support the hypothesis that antiinflammatory activity contributes to the mechanism of action of the inhibitor, and suggest that a selective inhibitor may effectively treat RA and other inflammatory disorders. Expand
Regulation of CD11b/CD18 expression in human neutrophils by phospholipase A2.
TLDR
The role of PLA2 as a key regulator of MAC-1 expression in models of neutrophil adhesion is emphasized, with reported data that MLD and SLD inactivate PLA2 through Schiff base formation. Expand
The role of strain variation in murine bleomycin-induced pulmonary fibrosis.
TLDR
Findings indicate that genetic variation influences the development of bleomycin-induced pulmonary fibrosis and this model may be useful as a basis to study the role of genetics in general fibrotic mechanisms. Expand
Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with
TLDR
From this work, (Z)-5-[[3,5-bis(1,1-dimethylethyl)-4- hydroxyphenyl]-methylene]-2-imino-4-thiazolidinone methanesulfonate salt was identified as a potent dual inhibitor of 5-lipoxygenase and cyclooxygen enzyme in the rat MFE model of inflammation. Expand
Role of chemokines and cytokines in a reactivation model of arthritis in rats induced by injection with streptococcal cell walls
TLDR
The data suggest that the late, mononuclear‐dependent phase of SCW‐induced arthritis in female Lewis rats requires cytokines that up‐regulate MCP‐1, which in turn may facilitate recruitment and extravasation of monon nuclear cells into the joint. Expand
Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.
TLDR
Di-tert-butylphenols 19 and 33 exhibit oral activity in various models of inflammation and, most importantly, are devoid of ulcerogenic potential. Expand
Streptococcal cysteine protease augments lung injury induced by products of group A streptococci
TLDR
Data demonstrate that SCP acts synergistically with other S. pyogenes products (SCW or SLO) to increase tissue injury and provide additional evidence that SCP may function as an important virulence factor in group A streptococcal infections. Expand
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