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Synaptic plasticity at hippocampal mossy fibre synapses
The dentate gyrus provides the main input to the hippocampus. Information reaches the CA3 region through mossy fibre synapses made by dentate granule cell axons. Synaptic plasticity at the mossyExpand
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Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro
Coherent oscillations, in which ensembles of neurons fire in a repeated and synchronous manner, are thought to be important in higher brain functions. In the hippocampus, these discharges areExpand
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Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learningExpand
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Kainate Receptors Depress Excitatory Synaptic Transmission at CA3→CA1 Synapses in the Hippocampus via a Direct Presynaptic Action
Kainate receptor activation depresses synaptic release of neurotransmitter at a number of synapses in the CNS. The mechanism underlying this depression is controversial, and both ionotropic andExpand
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Axo-Axonal Coupling A Novel Mechanism for Ultrafast Neuronal Communication
We provide physiological, pharmacological, and structural evidence that axons of hippocampal principal cells are electrically coupled, with prepotentials or spikelets forming the physiologicalExpand
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Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2
Autism spectrum disorders comprise a range of neurodevelopmental disorders characterized by deficits in social interaction and communication, and by repetitive behaviour. Mutations in synapticExpand
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Synaptic Activation of Presynaptic Kainate Receptors on Hippocampal Mossy Fiber Synapses
Kainate receptors (KARs) are a poorly understood family of ionotropic glutamate receptors. A role for these receptors in the presynaptic control of transmitter release has been proposed but remainsExpand
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RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release
Transmitter release at the fly neuromuscular junction is abolished in the absence of a scaffold protein. The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic activeExpand
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Coherent Phasic Excitation during Hippocampal Ripples
High-frequency hippocampal network oscillations, or "ripples," are thought to be involved in episodic memory. According to current theories, memory traces are represented by assemblies of principalExpand
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Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis
Febrile seizures are frequent during early childhood, and prolonged (complex) febrile seizures are associated with an increased susceptibility to temporal lobe epilepsy. The pathophysiologicalExpand
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