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The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance
TLDR
It is shown that the murine Foxl2 gene is essential for granulosa cell differentiation and ovary maintenance, and it is suggested that granULosa cell function is not only crucial for oocyte growth but also to maintain follicular quiescence in vivo. Expand
PIAS/SUMO: new partners in transcriptional regulation
TLDR
A model how the PIAS/ SUMO system may modulate transcriptional activities by mediating the assembly of coactivator or corepressor complexes within distinct subnuclear structures is proposed. Expand
CD44 variant isoforms associate with tetraspanins and EpCAM.
The metastasizing subline of the rat pancreatic adenocarcinoma BSp73 expresses a set of membrane molecules, the combination of which has not been detected on non-metastasizing tumor lines. Hence, itExpand
Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis.
TLDR
It is demonstrated that the AP-1 subunit junB is a target gene of hypoxia-induced signaling via NF-kappaB and identified JunB as a critical independent regulator of VEGF transcription and provides a mechanistic explanation for the inherent vascular phenotypes seen in JunB-deficient embryos, ex vivo allantois explants and in vitro differentiated embryoid bodies. Expand
The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7.
TLDR
Evidence for direct protein-protein interactions between EpCAM and claudin-7 was obtained by co-immunoprecipitation after treatment of tumor cells with a membrane-permeable chemical cross-linker. Expand
Critical role for NF‐κB‐induced JunB in VEGF regulation and tumor angiogenesis
TLDR
It is demonstrated that the AP‐1 subunit junB is a target gene of hypoxia‐induced signaling via NF‐κB and identified JunB as a critical independent regulator of VEGF transcription and provides a mechanistic explanation for the inherent vascular phenotypes seen in JunB‐deficient embryos, ex vivo allantois explants and in vitro differentiated embryoid bodies. Expand
Successful transplantation of human hepatoblastoma into immunodeficient mice.
TLDR
HB xenografts in immunodeficient mice are a feasible in vivo model for studies of the biological behavior of this tumor, and a dedifferentiation could not be clearly identified. Expand
The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation.
TLDR
The findings provide a convincing experimental explanation for the repeatedly described involvement of alpha6beta4 in tumor progression. Expand
The association of the tetraspanin D6.1A with the α6β4 integrin supports cell motility and liver metastasis formation
TLDR
A convincing experimental explanation is provided for the repeatedly described involvement of α6β4 in tumor progression by an interaction between α6 β4 and D6.1A complexes. Expand
The CD44 variant isoforms CD44v6 and CD44v7 are expressed by distinct leukocyte subpopulations and exert non-overlapping functional activities.
TLDR
Anti-CD44v6 and anti-CD 44v7 interfere with lymphocyte activation at very specific points in vivo and in vitro to clarify the mechanisms underlying the divergent functional activities of CD44 v6 and CD44v7. Expand
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