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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellularExpand
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Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid β-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular concentrationExpand
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A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress
Most protein phosphatases have little intrinsic substrate specificity, making selective pharmacological inhibition of specific dephosphorylation reactions a challenging problem. In a screen for smallExpand
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Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses
ABSTRACT Nuclear factor κB (NF-κB) serves to coordinate the transcription of genes in response to diverse environmental stresses. In this report we show that phosphorylation of the α subunit ofExpand
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Ultraviolet Light Activates NFκB through Translational Inhibition of IκBα Synthesis*
UV light induces a delayed and prolonged (3–20 h) activation of NFκB when compared with the immediate and acute (10–90 min) activation of NFκB in response to tumor necrosis factor α treatment. In theExpand
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Mechanisms of β-cell death in response to double-stranded (ds) RNA and interferon-γ dsrna-dependent protein kinase apoptosis and nitric oxide-dependent necrosis
Viral infection is one environmental factor that has been implicated as a precipitating event that may initiate β-cell damage during the development of diabetes. This study examines the mechanisms byExpand
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TumorSuppressionbyPTENRequirestheActivation of the PKR-eIF2a Phosphorylation Pathway
ttp D ow nladed from Inhibition of protein synthesis by phosphorylation of the a subunit of eukaryotic translation initiation factor 2 (eIF2) at Ser occurs as a result of the activation of a familyExpand
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Erratum: (Journal of Cell Biology (June 20, 2005) 169:6 (871-886))
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