• Publications
  • Influence
Neurocysticercosis. Two hundred thirty-eight cases from a California hospital.
  • D. Scharf
  • Medicine
  • Archives of neurology
  • 1 July 1988
Neurocysticercosis is no longer a medical curiosity in the United States. Two hundred thirty-eight patients with neurocysticercosis were studied between 1981 and 1986 at the Los AngelesExpand
  • 126
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Effects of anesthetics on the structure of a phospholipid bilayer: molecular dynamics investigation of halothane in the hydrated liquid crystal phase of dipalmitoylphosphatidylcholine.
We report the results of constant temperature and pressure molecular dynamics calculations carried out on the liquid crystal (Lalpha) phase of dipalmitoylphosphatidylcholine with a mole fraction ofExpand
  • 81
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Distribution of halothane in a dipalmitoylphosphatidylcholine bilayer from molecular dynamics calculations.
We report a 2-ns constant pressure molecular dynamics simulation of halothane, at a mol fraction of 50%, in the hydrated liquid crystal bilayer phase of dipalmitoylphosphatidylcholine. HalothaneExpand
  • 97
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A designed four-alpha-helix bundle that binds the volatile general anesthetic halothane with high affinity.
The structural features of volatile anesthetic binding sites on proteins are being examined with the use of a defined model system consisting of a four-alpha-helix bundle scaffold with a hydrophobicExpand
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Membrane structural perturbations caused by anesthetics and nonimmobilizers: a molecular dynamics investigation.
The structural perturbations of the fully hydrated dimyristoyl-phosphatidylcholine bilayer induced by the presence of hexafluoroethane C(2F6), a "nonimmobilizer," have been examined by molecularExpand
  • 42
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Magnifications: Photography With the Scanning Electron Microscope
magnifications: photography with the scanning electron magnifications photography with the scanning electron magnifications. photography with the scanning electron magnifications photography with theExpand
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Molecular dynamics simulation of a synthetic four‐α‐helix bundle that binds the anesthetic halothane
The structural features of binding sites for volatile anesthetics are examined by performing a molecular dynamics simulation study of the synthetic four‐α‐helix bundles (Aα2)2, which are formed byExpand
  • 13
Lipomas of the mesencephalic tectum and rostral pons associated with sleep apnea syndrome.
Two patients with mixed sleep apnea and autopsy-documented lipomas of the mesencephalic tectum and rostral pons are presented. Microscopically, the locus ceruleus was unilaterally invaded by a tumorExpand
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Towards an Understanding of How General Anesthetics Alter Central Nervous System Protein Function
C linical general anesthesia was introduced in 1856 by William Morton at the Massachusetts General Hospital in Boston. How inhaled anesthetics work at the molecular level remains poorly understood,Expand
  • 5
Viewing and Recording Live Hydrated Specimens with a High-Vacuum SEM
  • D. Scharf
  • Materials Science
  • Microscopy Today
  • 1 January 2017
As a standard preparation technique for the viewing and recording of biological specimens in the scanning electron microscope (SEM), the fixation, dehydration, and metal deposition of such specimensExpand
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