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Current Methods for Skeletal Muscle Tissue Repair and Regeneration
Skeletal muscle has the capacity of regeneration after injury. However, for large volumes of muscle loss, this regeneration needs interventional support. Consequently, muscle injury provides anExpand
Loss of RNF40 Decreases NF-&kgr;B Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice
BACKGROUND AND AIMS Inflammatory bowel diseases are linked to an increased risk of developing colorectal cancer [CRC]. Previous studies suggested that the H2B ubiquitin ligase RING finger protein-20Expand
Evaluation of ostarine as a selective androgen receptor modulator in a rat model of postmenopausal osteoporosis
Selective androgen receptor modulators (SARMs) have shown beneficial effects on muscle wasting, general physical function and bone properties in male mammals. However, data on the effects of SARMs inExpand
Determinants for success in climbing: A systematic review
Background The number of athletes engaged in climbing sports has risen. Specific physical and psychological skills are required. The objective of this review was to determine factors for highExpand
Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis
We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in aExpand
Epidemiology of vertebral fractures in pediatric and adolescent patients
Spinal injuries in children and adolescents are rare injuries, but consequences for the growing skeleton can be devastating. Knowledge of accident causes, clinical symptoms and diagnostics should beExpand
USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity
USP22, the deubiquitinating subunit of the SAGA transcriptional cofactor complex, is a member of an 11-gene “death-from-cancer” signature. USP22 has been considered an attractive therapeutic targetExpand
Effect of Strontium Ranelate on the Muscle and Vertebrae of Ovariectomized Rats
Osteoporosis is often accompanied by sarcopenia. The effect of strontium ranelate (SR) on muscle tissue has not been investigated sufficiently. In this study, the effect of different SR treatments onExpand
Effect of the lipoxygenase-inhibitors baicalein and zileuton on the vertebra in ovariectomized rats.
Osteoporosis is one of the most common diseases worldwide. In osteoporosis, vertebral fractures represent a major burden. Lipoxygenase (LOX) inhibitors such as baicalein and zileuton may represent aExpand
Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats
Sarcopenia, a loss of muscle mass accompanying osteoporosis, leads to falls and fall-related injuries. Baicalein, as a phytochemical agent, has an antioxidative and anti-inflammatory effect inExpand