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The genome of the model beetle and pest Tribolium castaneum
Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agriculturalExpand
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Functional and Evolutionary Insights from the Genomes of Three Parasitoid Nasonia Species
Parasitoid Wasp Genomes Parasitoid wasps, which prey on and reproduce in host insect species, play important roles in plant herbivore interactions, and may provide valuable tools in the biologicalExpand
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Caenorhabditis elegans Levamisole Resistance Geneslev-1, unc-29, and unc-38 Encode Functional Nicotinic Acetylcholine Receptor Subunits
We show that three of the eleven genes of the nematodeCaenorhabditis elegans that mediate resistance to the nematocide levamisole and to other cholinergic agonists encode nicotinic acetylcholineExpand
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Neuromuscular defects in a Drosophila survival motor neuron gene mutant.
Autosomal recessive spinal muscular atrophy (SMA) is linked to mutations in the survival motor neuron (SMN) gene. The SMN protein has been implicated at several levels of mRNA biogenesis and isExpand
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Neonicotinoids: insecticides acting on insect nicotinic acetylcholine receptors.
Imidacloprid is increasingly used worldwide as an insecticide. It is an agonist at nicotinic acetylcholine receptors (nAChRs) and shows selective toxicity for insects over vertebrates. Recent studiesExpand
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The Caenorhabditis elegans unc-63 Gene Encodes a Levamisole-sensitive Nicotinic Acetylcholine Receptor α Subunit*
The anthelmintic drug levamisole causes hypercontraction of body wall muscles and lethality in nematode worms. In the nematode Caenorhabditis elegans, a genetic screen for levamisole resistance hasExpand
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Insights into social insects from the genome of the honeybee Apis mellifera
Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes,Expand
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Genome Sequence of the Pea Aphid Acyrthosiphon pisum
The genome of the pea aphid shows remarkable levels of gene duplication and equally remarkable gene absences that shed light on aspects of aphid biology, most especially its symbiosis with Buchnera.
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Insect GABA Receptors: Splicing, Editing, and Targeting by Antiparasitics and Insecticides
Ionotropic GABA receptors are abundant in both vertebrate and invertebrate nervous systems, where they mediate rapid, mostly inhibitory synaptic transmission. A GABA-gated chloride channel subunitExpand
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Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection
Alzheimer's disease (AD), the major contributor to dementia in the elderly, involves accumulation in the brain of extracellular plaques containing the β-amyloid protein (Aβ) and intracellularExpand
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