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- Publications
- Influence
Analysis of protein-coding genetic variation in 60,706 humans
- Monkol Lek, K. Karczewski, +76 authors D. MacArthur
- Biology
- 30 October 2015
Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. Here we describe the aggregation and analysis of… Expand
Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, +479 authors E. K. Speliotes
- Biology, Medicine
- Nature
- 12 February 2015
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass… Expand
Discovery and Refinement of Loci Associated with Lipid Levels
- C. Willer, E. Schmidt, +256 authors G. Abecasis
- Medicine, Biology
- Nature Genetics
- 6 October 2013
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery… Expand
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- A. Morris, B. Voight, +201 authors M. McCarthy
- Biology, Medicine
- Nature Genetics
- 26 July 2012
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and… Expand
Defining the role of common variation in the genomic and biological architecture of adult human height
- A. Wood, T. Esko, +442 authors T. Frayling
- Biology, Medicine
- Nature Genetics
- 8 September 2014
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different… Expand
Large-scale association analysis identifies new risk loci for coronary artery disease
- P. Deloukas, S. Kanoni, +180 authors N. Samani
- Biology, Medicine
- Nature Genetics
- 2013
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance,… Expand
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
- B. F. Voight, Gina M. Peloso, +123 authors S. Kathiresan
- Medicine
- The Lancet
- 11 August 2012
Summary Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are… Expand
New genetic loci link adipose and insulin biology to body fat distribution
- D. Shungin, T. Winkler, +403 authors K. Mohlke
- Biology, Medicine
- Nature
- 16 December 2014
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body… Expand
Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases. We report here a genome-wide meta-analysis of 37,684 individuals with… Expand
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
- S. Jaiswal, P. Natarajan, +19 authors B. Ebert
- Medicine
- The New England journal of medicine
- 21 June 2017
BACKGROUND Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of an expanded somatic blood‐cell clone in persons without other hematologic abnormalities, is… Expand