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Wnt signaling promotes oncogenic transformation by inhibiting c-Myc–induced apoptosis
TLDR
It is found that Wnt/β-catenin signaling suppressed apoptosis by inhibiting c-Myc–induced release of cytochrome c and caspase activation and both cyclooxygenase 2 and WISP-1 were identified as effectors of the Wnt-mediated antiapoptotic signal. Expand
Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B.
TLDR
It is found that HNSCC cells underwent anoikis upon loss of matrix contact, whereas HGF provided protection against it, and HGF-induced anoIKis resistance was found to be dependent on both ERK and Akt signaling pathways. Expand
Hepatocyte Growth Factor Inhibits Anoikis in Head and Neck Squamous Cell Carcinoma Cells by Activation of ERK and Akt Signaling Independent of NFκB*
Hepatocyte growth factor (HGF), also known as a scatter factor, regulates a variety of biological activities including cell proliferation, survival, migration, and angiogenesis. Importantly, HGF andExpand
c-Myc Sensitizes Cells to Tumor Necrosis Factor-mediated Apoptosis by Inhibiting Nuclear Factor κB Transactivation*
TLDR
The results elucidate the molecular mechanisms by which c-Myc increases cell susceptibility to TNF-mediated apoptosis, indicating that c- myc may exhibit its pro-apoptotic activities by repression of cell survival genes. Expand
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
TLDR
The full contents of the supplement are available online at http://jitc.biomedcentral.com/articles/supplements/volume-4-supplement-1. Expand
WNT5a in Tongue and Fungiform Papilla Development
TLDR
Preliminary data from WNT5a mutant mice separate genetic programs for papilla number from those for tongue shape and size, and WNT/β‐catenin signaling is required for formation of fungiform papillae, but not for determining tongue size and shape. Expand
Abstract 2619: Combination of ECP1014 and anti-PD-L1 reduces tumor growth in the CT26 murine colon carcinoma model of a cold tumor
TLDR
The hypothesis was that combining ECP1014, which has shown potently decreases PGE2 in CT26, with a checkpoint inhibitor would increase immune response to the tumor, turning it “hot” and producing superior tumor control versus either agent alone. Expand
Abstract 5691: Evaluation of immunomodulatory agents in classically immunologically 'cold' cancers using syngeneic mouse models of breast and ovarian cancer
TLDR
These models of breast and ovarian cancer can be used to evaluate anti-tumor immune responses in immunologically more quiescent indications and high sensitivity to inhibitors of PD-1, PD-L1, and CTLA-4, although the activity of anti-PD-1 on established tumors was more modest. Expand
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