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Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists
TLDR
It is proposed that MCFA assay-specific actions are linked to their unique binding mode and suggest that it may be possible to identify selective PPARγ modulators with useful clinical profiles among natural products.
Mode of Peroxisome Proliferator-Activated Receptor γ Activation by Luteolin
TLDR
It is proposed that activities of luteolin are related to its singular binding mode, that anti-inflammatory activity does not require H12 stabilization, and that the structure can be useful in developing safe selective PPARγ modulators.
Analysis of agonist and antagonist effects on thyroid hormone receptor conformation by hydrogen/deuterium exchange.
TLDR
Hydrogen/deuterium exchange on TR LBDs with or without agonist (T(3)) or antagonist (NH3) is conducted, implying tighter overall folding of the domain and it is proposed that TR H12 interacts with this region in apo-TR and that this interaction is blocked by T(3) but not NH3.
Hyperalgesic and edematogenic effects of peptides isolated from the venoms of honeybee (Apis mellifera) and neotropical social wasps (Polybia paulista and Protonectarina sylveirae)
TLDR
Results indicate that melittin, Polybia-MP-I, N-2-Polybia- MPs, Protonectarina- MP-NH2, and ProtonECT-OH peptides could contribute to inflammation and pain induced by insect venoms.
Profiling the peptidome of the venom from the social wasp Agelaia pallipes pallipes.
TLDR
The venom was previously fractionated, and the sequences were obtained through the use of electrospray ionization with a tridimensional ion-trap and time-of-flight mass analysis under CID conditions, allowing easy sequencing of the three peptides presenting this post-translational modification.
Proteomic view of the venom from the fire ant Solenopsis invicta Buren.
TLDR
The combination of gel-based and gel-free proteomic strategies was used to assign the proteomic profile of the venom from the fire ant S. invicta and allowed the identification of 46 proteins, which were organized into four different groups according to their potential role in fire ant venom.
Agelaia MP-I: a peptide isolated from the venom of the social wasp, Agelaia pallipes pallipes, enhances insulin secretion in mice pancreatic islets.
TLDR
AMP-I increased beta cell secretion without interfering in K(ATP) and L-type Ca(2+) channel function, suggesting a different mechanism for this peptide, possibly by G protein interaction, due to the structural similarity of this peptides with Mastoparan-X.
Low-Resolution Molecular Models Reveal the Oligomeric State of the PPAR and the Conformational Organization of Its Domains in Solution
TLDR
Results reveal that, in contrast with other studied nuclear receptors, hPPARγ remains in the monomeric form by itself but forms heterodimers with hRXRα, and hydrogen/deuterium exchange experiments reveal that the heterodimer binding to DNA promotes more compact and less solvent-accessible conformation of the receptor complex.
Protonectin (1-6): a novel chemotactic peptide from the venom of the social wasp Agelaia pallipes pallipes.
TLDR
A comparison of the sequences of both peptides suggests that the sequence ILGTIL is conserved, suggesting that it must constitute a linear motif for the structural recognition by the specific receptor which induces leukocytes migration.
Mode of PPARγ Activation by Luteolin
TLDR
It is proposed that activities of luteolin are related to its singular binding mode, that anti-inflammatory activity does not require H12 stabilization and that the structure can be useful in developing safe selective PPARγ modulators.
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