• Publications
  • Influence
Evidence based medicine: what it is and what it isn't
It's about integrating individual clinical expertise and the best external evidence Evidence based medicine, whose philosophical origins extend back to mid-19th century Paris and earlier, remains aExpand
  • 11,859
  • 331
  • PDF
Users' guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine
You are back where we put you in the previous article1 on diagnostic tests in this series on how to use the medical literature: in the library studying an article that will guide you in interpretingExpand
  • 1,810
  • 80
  • PDF
Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators.
BACKGROUND Previous studies have shown that carotid endarterectomy in patients with symptomatic severe carotid stenosis (defined as stenosis of 70 to 99 percent of the luminal diameter) is beneficialExpand
  • 2,906
  • 75
Clinical epidemiology : a basic science for clinical medicine
I might have guessed that a book dedicated to "H.L. Mencken, Kurt Vonnegut, Jr., Douglas Adams, and the Emperor's New Clothes" would be fun to read. It was! Readers will sense the authors' enthusiasmExpand
  • 3,453
  • 58
Cochrane Collaboration
1 Penswick J, Wright AL. Skin necrosis induced by streptokinase. BMJ 1994;309:378. (6 August.) 2 Bucher A, Roald B. Kolesterolembolisering etter intravenos streptokinasebehandling ved akuttExpand
  • 1,858
  • 58
The number needed to treat: a clinically useful measure of treatment effect
The relative benefit of an active treatment over a control is usually expressed as the relative risk, the relative risk reduction, or the odds ratio. These measures are used extensively in bothExpand
  • 1,596
  • 54
  • PDF
An assessment of clinically useful measures of the consequences of treatment.
WITH neither the time nor the resources available to prevent, detect, or treat every disorder in every patient, which preventive, diagnostic, or therapeutic interventions should take priority? When aExpand
  • 1,457
  • 48
Users' Guides to the Medical Literature: III. How to Use an Article About a Diagnostic Test: B. What Are the Results and Will They Help Me In Caring for My Patients?
CLINICAL SCENARIO You are back where we put you in the previous article1on diagnostic tests in this series on how to use the medical literature: in the library studying an article that will guide youExpand
  • 1,864
  • 35
Bias in analytic research.
Publisher Summary This chapter focuses on the bias in analytic research. Case-control studies are attractive. They can be executed quickly and at low cost, even when the disorders of interest areExpand
  • 1,886
  • 33
  • PDF