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Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases
TLDR
These findings not only identify one way by which the immune system is alerted to malarial infection but also are one of the first to suggest a role for tyrosine kinase signaling pathways in regulation of the NLRP3 inflammasome. Expand
The structure of malaria pigment β-haematin
TLDR
The crystal structure of β-haematin determined using simulated annealing techniques to analyse powder diffraction data obtained with synchrotron radiation is reported, which has implications for understanding the action of current antimalarial drugs and possibly for the design of new therapeutic agents. Expand
Structural and morphological characterization of hemozoin produced by Schistosoma mansoni and Rhodnius prolixus
TLDR
Structural and morphological characterization of natural Hz samples obtained from these two blood‐feeding organisms are shown and it is shown that Hz formation occurring in close association to a hydrophobic environment seems to be a common trend for these organisms and may be crucial to produce very regular shaped phases. Expand
Modulation of Superoxide-dependent Oxidation and Hydroxylation Reactions by Nitric Oxide (*)
TLDR
In the absence of iron, equimolar fluxes of NO and O interact to yield potent oxidants such as ONOO/ONOOH, which oxidize organic compounds. Expand
Metabolic Fate of Peroxynitrite in Aqueous Solution
TLDR
It is demonstrated that peroxynitrite decomposes with significant rates to NO2− plus O2 at physiological pH, which may contribute to the physiology and/or cytotoxicity of NO and superoxide. Expand
The structure of malaria pigment beta-haematin.
TLDR
The crystal structure of beta-haematin determined using simulated annealing techniques to analyse powder diffraction data obtained with synchrotron radiation is reported, which has implications for understanding the action of current antimalarial drugs and possibly for the design of new therapeutic agents. Expand
Synthetic Plasmodium-Like Hemozoin Activates the Immune Response: A Morphology - Function Study
TLDR
A new method of HZ synthesis is reported that yields homogeneous sHZ crystals (Plasmodium-like HZ) which are very similar to PHZ in their size and physicochemical properties and are devoid of protein and DNA contamination. Expand
Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda.
TLDR
An ethnopharmacological investigation was conducted among the Baka pygmies of Dja biosphere reserve (Cameroon) to collect information on the antimalarial plants used in their daily life, and extracts of H. floribunda showed remarkable inhibitory activity against drug-resistant strains of Plasmodium falciparum. Expand
Sperm motility enhancement by nitric oxide produced by the oocytes of fathead minnows, Pimephelas promelas.
The effects of nitric oxide (NO) on sperm motility were examined in the fathead minnow, Pimephelas promelas, using computer-assisted sperm analysis (CASA). The observed effects underscore the dualExpand
Characterization of the Products of the Heme Detoxification Pathway in Malarial Late Trophozoites by X-ray Diffraction*
TLDR
Results unambiguously demonstrate that hemozoin crystallites are identical to synthetic β-hematin, an insoluble crystalline heme coordination polymer. Expand
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