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[Differences in the anxiety level of 2 rat strains can be determined by the density of benzodiazepine receptors in the brain].
The object of the present work was detection of the genetic differences in the anxiety level evaluated in a number of behavioral tests and according to the characteristics of benzodiazepine receptorsExpand
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[The genetic characteristics of the brain alpha 2-adrenergic and S2-serotoninergic systems in the realization of the tail-jerk pain reflex and its morphine suppression in rats].
Experiments were conducted on two inbred rat strains--WAG/G and Fischer-344. The WAG/G rats were found to increase the density of brain cortical mu-opiate and alpha 2-adrenergic receptors, shortExpand
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[The pharmacological properties of karazedin].
The original agent 1,2,3,4,5,5a,6,10b-octahydroazepino-[4,5-b]indole (carazedine), an analog of the highly active antipsychotic drug carbidine, was synthesized. This agent was found to have variousExpand
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[Differences in the characteristics of opiate and catecholaminergic receptors of the striatum and cerebral cortex of rats of Fisher-344 and WAG/GSto strains may cause differences in reinforced action
It has been shown that Fischer-344 rats more than WAG/GSto inbred rats preferred to consume the solution of morphine. In intravenous self-administration testing, Fischer-344 rats had a higher rate ofExpand
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[Interaction of piracetam with 3H-imipramine binding sites and the GAMA-benzodiazepine receptor complex of brain membranes].
Piracetam at a concentration of 10(-6) M was shown to behave as a noncompetitive inhibitor of 3H-imipramine specific binding to rat brain membranes. At the same time piracetam failed to influenceExpand
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[A method for the quantitative assessment of the withdrawal syndrome in morphine-dependent rats].
The evaluation of strength of morphine withdrawal syndrome in rats after the 17th day i. p. morphine administration is proposed as calculation of individual indexes in "open field" test. It is found,Expand
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[Effect of 1,2,3,4-tetrahydroimidazo[4,5-c]pyridine and 1,2,3,4-tetrahydroisoquinoline derivatives on the behavior and the brain receptor system in rats].
Adducts obtained via the interaction of formaldehyde with histidine (1,2,3,4-tetrahydroimidazo[4, 5-c]pyridine-3-carboxylic acid (I)), tyrosine (7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylicExpand
[Effect of chronic use of antidepressants on the state of benzodiazepine receptors in the mouse brain].
A study was made of the effect of a two-week administration of chlorimipramine, zimelidine and a morpholine derivative on benzodiazepine receptors of the mouse brain. The animals which receivedExpand
[Effect of chronic administration of antidepressants on the binding of 3H-imipramine with mouse brain synaptic membranes].
Subchronic (14 days) administration of chlorimipramine and zimelidine, and a new morpholine derivative produces different effects on 3H-imipramine binding with synaptic membranes of the mouse brain.Expand