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Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling.
The stromal microenvironment in human prostate cancer is altered compared with normal stroma and exhibits features of a wound repair stroma, and it is suggested that TGF-beta1 is a candidate regulator of reactive stroma during prostate cancer progression. Expand
Reactive stroma in prostate cancer progression.
Reactive stroma in prostate cancer and granulation tissue in wound repair show similar biological responses and processes that are predicted to promote cancer progression. Expand
The reactive stroma microenvironment and prostate cancer progression.
The biology of reactive stroma in cancer is similar to the more predictable biology of the stroma compartment during wound repair at sites where the epithelial barrier function is breached and a stromal response is generated. Expand
Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer.
This is the first study to demonstrate that nonepithelial-reactive stroma elements in prostate cancer tumors can be used as prognostic indicators and add to the concept that tumors are not purely epithelial and the tumor-re active stroma must be considered an important biological component of the cancer. Expand
Stromogenic prostatic carcinoma pattern (carcinomas with reactive stromal grade 3) in needle biopsies predicts biochemical recurrence-free survival in patients after radical prostatectomy.
Quantitation of reactive stroma and recognition of the stromogenic carcinoma in H&E-stained biopsies is useful to predict biochemical recurrence in prostate carcinoma patients independent of Gleason grade and prostate-specific antigen. Expand
Cancer-Related Axonogenesis and Neurogenesis in Prostate Cancer
This is the first description of cancer-related neurogenesis and its putative regulatory mechanism and two in vitro models confirmed that cancer cells, particularly when interacting with nerves in perineural invasion, induce neurite outgrowth in prostate cancer. Expand
Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model.
Findings point to the stromal compartment as a potential source of new prognostic markers and therapeutic targets and show the utility of the carcinoma-stromal xenograft model system in dissecting specific mechanisms of reactive stroma. Expand
Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis.
Our previous studies have defined reactive stroma in human prostate cancer and have developed the differential reactive stroma (DRS) xenograft model to evaluate mechanisms of how reactive stromaExpand
Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma.
The value of co-targeting both CAFs and cancer cells to increase the benefits of T-cell immunotherapy for solid tumors is highlighted, with a survival advantage compared to either alone. Expand
The functional role of reactive stroma in benign prostatic hyperplasia.
  • I. Schauer, D. Rowley
  • Biology, Medicine
  • Differentiation; research in biological diversity
  • 1 November 2011
The dissection of important factors, signaling pathways, genes, and other regulatory components that mediate the interplay between epithelium and stromal responses in BPH are addressed. Expand