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Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
Insulin resistance is a major factor in the pathogenesis of type 2 diabetes in the elderly. To investigate how insulin resistance arises, we studied healthy, lean, elderly and young participantsExpand
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Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity.
To determine the relationship between cerebral Glc metabolism and glutamatergic neuronal function, we used 13C NMR spectroscopy to measure, simultaneously, the rates of the tricarboxylic acid cycleExpand
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Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity.
To examine the mechanism by which free fatty acids (FFA) induce insulin resistance in human skeletal muscle, glycogen, glucose-6-phosphate, and intracellular glucose concentrations were measuredExpand
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Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study
Summary Recent muscle biopsy studies have shown a relation between intramuscular lipid content and insulin resistance. The aim of this study was to test this relation in humans by using a novelExpand
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Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression.
BACKGROUND Measurement of cortical gamma-aminobutyric acid (GABA) and glutamate concentrations is possible using proton magnetic resonance spectroscopy. An initial report, using this technique,Expand
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Mechanism of free fatty acid-induced insulin resistance in humans.
To examine the mechanism by which lipids cause insulin resistance in humans, skeletal muscle glycogen and glucose-6-phosphate concentrations were measured every 15 min by simultaneous 13C and 31PExpand
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Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.
Localized 1H NMR spectroscopy in conjunction with J editing was used to measure the concentration of gamma-aminobutyric acid (GABA) in the occipital lobe of four control human volunteers and fourExpand
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Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.
Brain lactate concentration is usually assumed to be stable except when pathologic conditions cause a mismatch between glycolysis and respiration. Using newly developed 1H NMR spectroscopicExpand
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Neuronal–Glial Glucose Oxidation and Glutamatergic–GABAergic Function
Prior 13C magnetic resonance spectroscopy (MRS) experiments, which simultaneously measured in vivo rates of total glutamate-glutamine cycling (Vcyc(tot)) and neuronal glucose oxidation (CMRglc(ox),Expand
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High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo
Comprehensive and quantitative measurements of T1 and T2 relaxation times of water, metabolites, and macromolecules in rat brain under similar experimental conditions at three high magnetic fieldExpand
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