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Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract
Although epithelial ovarian cancers (EOCs) have been thought to arise from the simple epithelium lining the ovarian surface or inclusion cysts, the major subtypes of EOCs show morphologic featuresExpand
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Potential markers that complement expression of CA125 in epithelial ovarian cancer.
BACKGROUND When ovarian carcinoma is diagnosed in stage I, up to 90% of patients can be cured with surgery and currently available chemotherapy. At present, less than 25% of cases are diagnosed atExpand
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Expression of progesterone receptor is a favorable prognostic marker in ovarian cancer.
OBJECTIVE Receptors for estrogen (ER), progesterone (PR), or androgen (AR) are predictive and prognostic markers of malignancy of multiple endocrine organs, including endometrial and breast cancer.Expand
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Selection of Potential Markers for Epithelial Ovarian Cancer with Gene Expression Arrays and Recursive Descent Partition Analysis
Purpose: Advanced-stage epithelial ovarian cancer has a poor prognosis with long-term survival in less than 30% of patients. When the disease is detected in stage I, more than 90% of patients can beExpand
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The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
  • G. Yang, D. Rosen, +5 authors J. Liu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 31 October 2006
Epithelial–stromal interactions play a critical role in tumor initiation and progression; cancer-associated stroma, but not normal stroma, is known to be tumor-promoting. However, the molecularExpand
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Mitochondrial Manganese-Superoxide Dismutase Expression in Ovarian Cancer
Superoxide dismutases (SODs) are important antioxidant enzymes responsible for the elimination of superoxide radical (\batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb}Expand
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GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex
Significance Androgen receptor (AR) signaling is a key driver of prostate cancer (PC), even in the context of resistance to current therapies, creating an unmet need for novel approaches to inhibitExpand
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Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer
Individual classes of human endogenous retrovirus (HERV) genes and proteins are expressed in cancer, but expression of more than one type of HERV is rare. We report here the expression of multipleExpand
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CXCR2 Promotes Ovarian Cancer Growth through Dysregulated Cell Cycle, Diminished Apoptosis, and Enhanced Angiogenesis
Purpose: Chemokine receptor CXCR2 is associated with malignancy in several cancer models; however, the mechanisms involved in CXCR2-mediated tumor growth remain elusive. Here, we investigated theExpand
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Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.
We show that atypical PKCiota, which plays a critical role in the establishment and maintenance of epithelial cell polarity, is genomically amplified and overexpressed in serous epithelial ovarianExpand
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