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The neurobiology of aggression and violence.
Aggression and violence represent a significant public health concern and a clinical challenge for the mental healthcare provider. A great deal has been revealed regarding the neurobiology ofExpand
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PSA-NCAM expression in the piriform cortex of the adult rat. Modulation by NMDA receptor antagonist administration
Administration of NMDA receptor antagonists upregulates the expression of the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) in the adult hippocampus. Since the piriform cortexExpand
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NMDA receptor antagonist treatment induces a long‐lasting increase in the number of proliferating cells, PSA‐NCAM‐immunoreactive granule neurons and radial glia in the adult rat dentate gyrus
During adulthood, neural precursors located in the subgranular zone of the dentate gyrus continue to proliferate, leading to the generation of new granule neurons. These recently generated cellsExpand
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NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus
The production of new neurons declines during adulthood and persists, although at very low levels, in the aged hippocampus. Since neurogenesis in young adults has been related to learning and memory,Expand
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Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: Reversal by tianeptine
Excitatory amino acids play a key role in stress-induced remodeling of dendrites in the hippocampus as well as in suppression of neurogenesis in the dentate gyrus. The regulation of extracellularExpand
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Schizotypal Personality Disorder: A Current Review
The study of schizotypal personality disorder (SPD) is important clinically, as it is understudied, challenging to treat, often under-recognized or misdiagnosed, and associated with significantExpand
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Widespread expression of rat collapsin response‐mediated protein 4 in the telencephalon and other areas of the adult rat central nervous system
The rat collapsin response‐mediated protein 4 (rCRMP‐4) is a member of a family of proteins that are involved in axonal growth. It is found transiently in postmitotic neurons, such as those that areExpand
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Estrogen and Ovariectomy Regulate mRNA and Protein of Glutamic Acid Decarboxylases and Cation-Chloride Cotransporters in the Adult Rat Hippocampus
17β-Estradiol spatiotemporally regulates the γ-aminobutyric acid (GABAergic) tone in the adult hippocampus. However, the complex estrogenic effect on the GABAergic system is still unclear. In adultExpand
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Serotonin transporter availability in impulsive aggressive personality disordered patients: a PET study with [11C]DASB.
Serotonin (5-HT) has consistently been implicated in the pathophysiology of impulsive aggression. In the current study, we tested the hypothesis that 5-HT transporter (5-HTT) binding is reduced inExpand
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Effects of the D1 Dopamine Receptor Agonist Dihydrexidine (DAR-0100A) on Working Memory in Schizotypal Personality Disorder
Pharmacological enhancement of prefrontal D1 dopamine receptor function remains a promising therapeutic approach to ameliorate schizophrenia-spectrum working memory deficits, but has yet to beExpand
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