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Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet–Induced Metabolic Syndrome
Dietary polyphenols protect against metabolic syndrome, despite limited absorption and digestion, raising questions about their mechanism of action. We hypothesized that one mechanism may involve the… Expand
The role of adenovirus E4orf4 protein in viral replication and cell killing
It has only been within the last few years that insights have been gained into the remarkable diversity of functions of the adenovirus early transcription region 4 (E4) products. The polypeptide… Expand
Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A
- D. Roopchand, J. M. Lee, S. Shahinian, D. Paquette, H. Bussey, P. Branton
- Medicine, Biology
- 30 August 2001
The E4orf4 protein of human adenovirus induces p53-independent apoptosis, a process that may promote cell death and viral spread. When expressed alone, E4orf4 kills transformed cells but not normal… Expand
Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice.
- D. Roopchand, P. Kuhn, L. E. Rojo, M. Lila, I. Raskin
- Medicine, Biology
- Pharmacological research
- 1 February 2013
Defatted soybean flour (DSF) can sorb and concentrate blueberry anthocyanins and other polyphenols, but not sugars. In this study blueberry polyphenol-enriched DSF (BB-DSF) or DSF were incorporated… Expand
Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1).
The TNO intestinal model (TIM-1) of the human upper gastrointestinal tract was used to compare intestinal absorption/bioaccessibility of blueberry anthocyanins under different digestive conditions.… Expand
Efficient sorption of polyphenols to soybean flour enables natural fortification of foods.
The present study demonstrated that defatted soybean flour (DSF) can sorb polyphenols from blueberry and cranberry juices while separating them from sugars. Depending on DSF concentration and juice… Expand
Adenovirus Protein E4orf4 Induces Premature APCCdc20 Activation in Saccharomyces cerevisiae by a Protein Phosphatase 2A-Dependent Mechanism
- Melissa Z. Mui, D. Roopchand, Matthew S Gentry, R. Hallberg, J. Vogel, P. Branton
- Medicine, Biology
- Journal of Virology
- 17 February 2010
ABSTRACT Protein phosphatase 2A (PP2A) has been implicated in cell cycle progression and mitosis; however, the complexity of PP2A regulation via multiple B subunits makes its functional… Expand
Food-compatible method for the efficient extraction and stabilization of cranberry pomace polyphenols.
- D. Roopchand, C. Krueger, K. Moskal, B. Fridlender, M. Lila, I. Raskin
- Chemistry, Medicine
- Food chemistry
- 15 December 2013
Cranberry pomace is a byproduct of cranberry processing and is comprised of seeds, skins and stems of the cranberry fruit. While cranberry pomace contains beneficial polyphenols, including… Expand
Genetic Analysis of B55α/Cdc55 Protein Phosphatase 2A Subunits: Association with the Adenovirus E4orf4 Protein
ABSTRACT The human adenovirus E4orf4 protein is toxic in both human tumor cells and Saccharomyces cerevisiae. Previous studies indicated that most of this toxicity is dependent on an interaction of… Expand
Grape proanthocyanidin-induced intestinal bloom of Akkermansia muciniphila is dependent on its baseline abundance and precedes activation of host genes related to metabolic health.
- L. Zhang, R. Carmody, +8 authors D. Roopchand
- Biology, Medicine
- The Journal of nutritional biochemistry
- 1 June 2018
We previously showed that C57BL/6J mice fed high-fat diet (HFD) supplemented with 1% grape polyphenols (GP) for 12 weeks developed a bloom of Akkermansia muciniphila with attenuated metabolic… Expand