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p63 is a p53 homologue required for limb and epidermal morphogenesis
P63 is essential for several aspects of ectodermal differentiation during embryogenesis, including hair follicles, teeth and mammary glands, which are absent in p63-deficient mice. Expand
p63 is the molecular switch for initiation of an epithelial stratification program.
The data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis. Expand
Multiple defects and perinatal death in mice deficient in follistatin
Follistatin-deficient mice are retarded in then* growth, have decreased mass of the diaphragm and intercostal muscles, shiny taut skin, skeletal defects of the hard palate and the thirteenth pair of ribs, their whisker and tooth development is abnormal, they fail to breathe, and die within hours of birth, indicating that follistatin may modulate the actions of several members of the transforming growth factor-β family. Expand
Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro
In vitro results suggest that the Ca2+ environment is a fundamental regulator of expression of epidermal differentiation markers and provide an explanation for the existence of theCa2+ gradient in vivo. Expand
Deregulated expression of c-Myc depletes epidermal stem cells
It is concluded that deregulated expression of c-Myc in stem cells reduces β1 integrin expression, which is essential to both keratinocyte migration and stem cell maintenance. Expand
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
These experiments show that Keap1 acts upstream of Nrf2 in the cellular response to oxidative and xenobiotic stress, and breeding to NRF2-deficient mice reversed the phenotypic Keap 1 deficiencies. Expand
Functional analysis of activins during mammalian development
Mice lacking both activin subunits show the defects of both individual mutants but no additional defects, indicating that there is no functional redundancy between these proteins during embryogenesis. Expand
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.
A complex cross-talk between Notch and p63 is involved in the balance between keratinocyte self-renewal and differentiation, with the Hes-1 gene as one of its direct negative targets. Expand
Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment.
The data suggest that cortical TEC development proceeds from a K8(+)K5(+) precursor subset to a K4(-)CD8(-)K5 (+) stage in a differentiation process concomitant with T-cell lineage commitment. Expand
Mechanisms regulating epithelial stratification.
  • M. Koster, D. Roop
  • Biology, Medicine
  • Annual review of cell and developmental biology
  • 18 October 2007
This review summarizes the current advances that have been made in understanding the molecular mechanisms that regulate epidermal morphogenesis and outlines the priorities for further research. Expand