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Recent Advances in Lipase-Mediated Preparation of Pharmaceuticals and Their Intermediates
TLDR
This review critically reports and discusses examples from recent literature, concerning the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and their intermediates in which the key step involves the action of a lipase.
New insights on the features of the vinyl phenol reductase from the wine-spoilage yeast Dekkera/Brettanomyces bruxellensis
TLDR
A bioinformatics analysis of the sequence of vinyl phenol reductase/superoxide dismutase from D. bruxellensis CBS 4481 reveals the presence in this protein of cofactor-binding structural features, that are absent in sequences of superoxide dismUTases from related microorganisms, that do not display vinyl Phenol reducase activity.
Marine Microorganisms as Source of Stereoselective Esterases and Ketoreductases: Kinetic Resolution of a Prostaglandin Intermediate
TLDR
A screening among bacterial strains isolated from water-brine interface of the deep hypersaline anoxic basins of the Eastern Mediterranean was carried out for the biocatalytical resolution of racemic propyl ester of anti-2-oxotricyclo (R,S)-1, a key intermediate for the synthesis of d-cloprostenol.
Stereoselective Reduction of 2‐Hydroxy Ketones towards syn‐ and anti‐1,2‐Diols
TLDR
Biocatalytic transformations enable a process which is hardly accessible through present non-enzymatic methods, and an efficient two-step bioc atalytic method for the synthesis of syn-1,2-diols is described.
Solid state fermentation for the production of lipolytic fungal enzymes
TLDR
The production of lypolitic moulds in solid state fermentation was studied using different media to form various geranyl esters with molar conversions ranging from 40 to 95%, under optimised conditions.
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