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Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.
HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity
- Mitchell R. McGill, Hui-min Yan, A. Ramachandran, Gordon J Murray, D. Rollins, H. Jaeschke
- Biology, MedicineHepatology
- 1 March 2011
Evidence is presented that the cell line HepaRG is a useful human model for the study of APAP‐induced liver injury and key mechanistic features of AP AP‐induced cell death are the same in human Hepa RG cells, rodent in vivo models, and primary cultured mouse hepatocytes.
The impact of cocaine and marijuana use on low birth weight and preterm birth: a multicenter study.
A novel validated procedure for the determination of nicotine, eight nicotine metabolites and two minor tobacco alkaloids in human plasma or urine by solid-phase extraction coupled with liquid…
The incorporation of drugs into hair: relationship of hair color and melanin concentration to phencyclidine incorporation.
It is demonstrated that PCP is incorporated into black hair to a greater extent than yellow or nonpigmented hair and the data suggest that despite variations in PCP concentration because of hair color, they may be normalized by using the ratio of eumelan in to pheomelanin rather than hair weight.
Biliary Excretion of Drugs in Man
Bile may serve as an alternate route of elimination in renal failure, but this has not been determined in man and lack of reliable information regarding the biliary excretion of drugs in man is partly due to the relative inaccessibility of the human biliary tract.
The prevalence of drugs and alcohol in fatally injured truck drivers.
Impairment due to marijuana use was a factor in all cases where the delta-9-tetrahydrocannabinol concentration exceeded 1.0 ng/mL and that alcohol impairment contributed to all accidents where the blood alcohol concentration was 0.04% wt/vol or greater.
Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells
- Yuchao Xie, Mitchell R. McGill, H. Jaeschke
- Medicine, BiologyXenobiotica; the fate of foreign compounds in…
- 27 August 2015
It is found that APAP-protein adducts were lower at early time points and peaked around the time of peak liver injury, suggesting that these adduct levels may take longer to become elevated or remain elevated than previously thought.
Cocaine, benzoylecgonine, amphetamine, and N-acetylamphetamine binding to melanin subtypes.
- C. Borges, J. Roberts, D. Wilkins, D. Rollins
- Biology, ChemistryJournal of analytical toxicology
- 1 April 2003
Findings show that basic drugs have a greater affinity for melanin than their net neutral analogues, reveal that melanin types differ when it comes to drug binding, help elucidate what properties of melanin are important for drugbinding, and help explain why hair color biases exist.
The incorporation of cocaine and metabolites into hair: effects of dose and hair pigmentation.
- D. L. Hubbard, D. Wilkins, D. Rollins
- MedicineDrug metabolism and disposition: the biological…
- 1 December 2000
It is demonstrated that the pigment-mediated differences in the incorporation of COC and its metabolites noted at 14 days after dosing are also evident a few hours after drug administration.