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A Pax3/Pax7-dependent population of skeletal muscle progenitor cells
During vertebrate development, successive phases of embryonic and fetal myogenesis lead to the formation and growth of skeletal muscles. Although the origin and molecular regulation of the earliestExpand
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Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD
We analyzed Pax-3 (splotch), Myf-5 (targeted with nlacZ), and splotch/Myf-5 homozygous mutant mice to investigate the roles that these genes play in programming skeletal myogenesis. In splotch andExpand
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Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells
The growth and repair of skeletal muscle after birth depends on satellite cells that are characterized by the expression of Pax7. We show that Pax3, the paralogue of Pax7, is also present in bothExpand
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Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
In vertebrates, skeletal muscle is a model for the acquisition of cell fate from stem cells. Two determination factors of the basic helix–loop–helix myogenic regulatory factor (MRF) family, Myf5 andExpand
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The formation of skeletal muscle: from somite to limb
During embryogenesis, skeletal muscle forms in the vertebrate limb from progenitor cells originating in the somites. These cells delaminate from the hypaxial edge of the dorsal part of the somite,Expand
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A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb.
We address the molecular control of myogenesis in progenitor cells derived from the hypaxial somite. Null mutations in Pax3, a key regulator of skeletal muscle formation, lead to cell death in thisExpand
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Divergent functions of murine Pax3 and Pax7 in limb muscle development.
Pax genes encode evolutionarily conserved transcription factors that play critical roles in development. Pax3 and Pax7 constitute one of the four Pax subfamilies. Despite partially overlappingExpand
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Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression
Skeletal muscle stem cells are regulated by Pax3/7. During development, Pax3 is required for the maintenance of these cells in the somite and their migration to sites of myogenesis; high levels ofExpand
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Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice
MICE that have mutations in both myogenic transcription factors Myf-5 and MyoD totally lack skeletal muscle fibres and their precursor myoblasts1, whereas with either mutation alone, muscle isExpand
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A beta-galactosidase hybrid protein targeted to nuclei as a marker for developmental studies.
The Escherichia coli lacZ gene has been used as an indicator gene for the study of cell lineage in vivo. To adapt this marker for gene expression studies, a sequence encoding a modifiedExpand
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