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Identification of specific sites of hormonal regulation in spermatogenesis in rats, monkeys, and man.
Drawing together data from rat, monkey, and human models, differences between species are identified and an overview of the hormonal regulation of spermatogenesis is formed based on the use of well-defined in vivo models of gonadotropin/androgen deprivation and replacement, the quantitative assessment of germ cell number using stereological techniques, and the directed study of specific steps in sperMatogenesis shown to be hormone dependent. Expand
Hormonal changes in the menopause transition.
Symptoms of the menopause can be interpreted as resulting primarily from the profound fall in estradiol, occurring over a 3- to 4-year period around final menses, a fall that presumably contributes importantly to the beginning, in the late perimenopause, of loss of bone mineral density. Expand
A review of hormonal changes during the menopausal transition: focus on findings from the Melbourne Women's Midlife Health Project.
In the post-menopause, FSH levels are markedly raised, E2 levels are low, whereas inhibin B and AMH are undetectable, a time of marked hormonal instability. Expand
Two Distinct Regions of Latency-associated Peptide Coordinate Stability of the Latent Transforming Growth Factor-β1 Complex*
Using in vitro mutagenesis, the regions of LAP are identified that govern the cooperative assembly and stability of the latent TGF-β1 complex and genetic mutations in LAP that cause the rare bone disorder Camurati-Engelmann disease disrupted dimerization and reduced the stability of that complex. Expand
Isolation of inhibin from bovine follicular fluid.
Bovine follicular fluid was used as a source for the isolation of gonadal inhibin, the activity of which was monitored by the dose dependent suppression of the FSH content of cultured pituitaryExpand
Antagonists of activin signaling: mechanisms and potential biological applications
Understanding how activin signaling is controlled extracellularly is the first step in providing treatment for wound healing and for disorders such as cachexia and cancer, which result from a deregulated activin pathway. Expand
Effects of testosterone plus medroxyprogesterone acetate on semen quality, reproductive hormones, and germ cell populations in normal young men.
It is concluded that the addition of DMPA hastens the onset of FSH/LH suppression, correlating with a more rapid impairment of spermatogonial development, but in the longer term, neither germ cell number nor sperm count differed. Expand
Activin A and inhibin A differentially regulate human uterine matrix metalloproteinases: potential interactions during decidualization and trophoblast invasion.
Data support that activin, via effects on MMPs, is an important factor in the maternal-fetal dialog regulating implantation, and suggests that inhibin may have a role in the cessation of vascular invasion. Expand
Testosterone promotes the conversion of round spermatids between stages VII and VIII of the rat spermatogenic cycle.
It is proposed that the principal action of T is to facilitate the maturation of round to elongated spermatids during spermiogenesis, and it is concluded that the conversion of round sperMatids between stages VII and VIII is a highly T-dependent step during s permiogenesis. Expand
Expression of nodal signalling components in cycling human endometrium and in endometrial cancer
The expression of Nodal in normal and malignant endometrial cells that lack Lefty strongly supports an important role for this embryonic morphogen in the tissue remodelling events that occur across the menstrual cycle and in tumourogenesis. Expand