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The natural history of familial cavernous malformations: results of an ongoing study.
TLDR
It is demonstrated that the familial form of cavernous malformations is a dynamic disease; serial MR images revealed changes in the number, size, and imaging characteristics of lesions consistent with acute or resolving hemorrhage, and that significant changes in neurological symptoms warrant repeat MR imaging.
Hemangioblastomas of the Central Nervous System in von Hippel-Lindau Syndrome and Sporadic Disease
TLDR
Because patients with VHL syndrome are at risk for development of new lesions, they require lifelong follow-up and neuroradiological screening allows identification of lesions before they become symptomatic in patients with CNS hemangioblastomas.
Spinal epidural abscess: contemporary trends in etiology, evaluation, and management.
TLDR
The frequency of diagnosis of spinal epidural abscess is increasing and patients with localized back pain who are at risk for developing such abscesses or who have an increased erythrocyte sedimentation rate and/or neurologic deficit should have an immediate MRI scan with contrast enhancement.
Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation.
TLDR
Data suggest that beta1 integrin and krit1 compete for the same site on icap1alpha, perhaps constituting a regulatory mechanism.
Spinal epidural abscess: a report of 40 cases and review.
TLDR
A significant increase in the incidence of epidural abscess after June 1988 is reported, and surgical drainage with sustained intravenous antibiotic treatment remains the cornerstone of therapy.
Cavernous malformations: natural history, diagnosis and treatment
TLDR
The current understanding of lesion pathophysiology is discussed and the controversial issues in the management of CMs are explored, such as when to use radiosurgery or surgery in deep-seated lesions, the treatment of epilepsy, and the safety of anticoagulation.
Brain capillary telangiectasia: MR imaging appearance and clinicohistopathologic findings.
TLDR
Capillary telangiectasia has mild contrast material enhancement but is otherwise undetectable on conventional MR images and demonstrates increased susceptibility only on GRE images, likely owing to blood oxygen-level-dependent contrast.
Cerebral cavernous malformations. Incidence and familial occurrence.
TLDR
It is concluded that cavernous malformations are more prevalent than previously reported, and that a familial form of the disorder exists that is more common than expected, with a high incidence of multiple lesions and an increased frequency of occurrence among Mexican-American families.
Routine intraoperative angiography during aneurysm surgery.
TLDR
In the surgical treatment of intracranial aneurysms, the use of routine intraoperative angiography is safe and helpful in a significant number of cases, although it does not replace careful intraoperative inspection of the surgical field.
Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations.
TLDR
The absence of blood-brain barrier components may lead to leakage of red blood cells into these lesions and the surrounding brain in the absence of major haemorrhage, thus accounting for the propensity of cavernous malformations to cause seizures.
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