The natural history of familial cavernous malformations: results of an ongoing study.
It is demonstrated that the familial form of cavernous malformations is a dynamic disease; serial MR images revealed changes in the number, size, and imaging characteristics of lesions consistent with acute or resolving hemorrhage, and that significant changes in neurological symptoms warrant repeat MR imaging.
Hemangioblastomas of the Central Nervous System in von Hippel-Lindau Syndrome and Sporadic Disease
- J. Conway, D. Chou, R. Clatterbuck, H. Brem, D. Long, D. Rigamonti
- 1 January 2001
Because patients with VHL syndrome are at risk for development of new lesions, they require lifelong follow-up and neuroradiological screening allows identification of lesions before they become symptomatic in patients with CNS hemangioblastomas.
Spinal epidural abscess: contemporary trends in etiology, evaluation, and management.
Spinal epidural abscess: a report of 40 cases and review.
Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord
- Yuxuan Wang, S. Springer, C. Bettegowda
- Biology, MedicineProceedings of the National Academy of Sciences
- 20 July 2015
It is shown here that primary CNS malignancies shed detectable levels of tumor DNA into the surrounding cerebrospinal fluid (CSF), which could serve as a sensitive and exquisitely specific marker for quantifying tumor burden without invasive biopsies.
Cavernous malformations: natural history, diagnosis and treatment
- S. Batra, D. Lin, P. Recinos, Jun Zhang, D. Rigamonti
- MedicineNature Reviews Neurology
- 1 December 2009
The current understanding of lesion pathophysiology is discussed and the controversial issues in the management of CMs are explored, such as when to use radiosurgery or surgery in deep-seated lesions, the treatment of epilepsy, and the safety of anticoagulation.
Cerebral cavernous malformations. Incidence and familial occurrence.
It is concluded that cavernous malformations are more prevalent than previously reported, and that a familial form of the disorder exists that is more common than expected, with a high incidence of multiple lesions and an increased frequency of occurrence among Mexican-American families.
Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation.
- J. Zhang, R. Clatterbuck, D. Rigamonti, D. Chang, H. Dietz
- BiologyHuman Molecular Genetics
- 1 December 2001
Data suggest that beta1 integrin and krit1 compete for the same site on icap1alpha, perhaps constituting a regulatory mechanism.
Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations
- R. Clatterbuck, C. Eberhart, B. Crain, D. Rigamonti
- Medicine, BiologyJournal of Neurology Neurosurgery & Psychiatry
- 1 August 2001
The absence of blood-brain barrier components may lead to leakage of red blood cells into these lesions and the surrounding brain in the absence of major haemorrhage, thus accounting for the propensity of cavernous malformations to cause seizures.
The MRI appearance of cavernous malformations (angiomas).
- D. Rigamonti, B. Drayer, P. Johnson, M. Hadley, J. Zabramski, R. Spetzler
- MedicineJournal of Neurosurgery
- 1 October 1987
The angiographic, computerized tomography, and magnetic resonance imaging findings were compared in 10 patients with a total of 16 pathologically verified cavernous angiomas and the combination of a reticulated core of mixed signal intensity (SI) with a surrounding rim of decreased SI strongly suggests the diagnosis of a cavernous malformation.