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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
LIMB muscles develop from cells that migrate from the somites1,2. The signal that induces migration of myogenic precursor cells to the limb emanates from the mesenchyme of the limb bud2,3. Here weExpand
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Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
Neuregulins and their specific receptors, members of the ErbB family of tyrosine kinases, have been implicated in the control of growth and development of Schwann cells, specialized cells that wrapExpand
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V1 spinal neurons regulate the speed of vertebrate locomotor outputs
The neuronal networks that generate vertebrate movements such as walking and swimming are embedded in the spinal cord. These networks, which are referred to as central pattern generators (CPGs), areExpand
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A stomatin-domain protein essential for touch sensation in the mouse
Touch and mechanical pain are first detected at our largest sensory surface, the skin. The cell bodies of sensory neurons that detect such stimuli are located in the dorsal root ganglia, and subtypesExpand
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DeltaNp73 regulates neuronal survival in vivo
Apoptosis occurs widely during brain development, and p73 transcription factors are thought to play essential roles in this process. The p73 transcription factors are present in two forms, the fullExpand
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A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.
The Ca(2+)-dependent cell adhesion molecule E-cadherin functions in the establishment and maintenance of epithelial cell morphology during embryogenesis and adulthood. Downregulation or completeExpand
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Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.
Signals transduced by the met tyrosine kinase, which is the receptor for scatter factor/hepatocyte growth factor, are of major importance for the regulation of epithelial cell motility,Expand
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Epibranchial ganglia orchestrate the development of the cranial neurogenic crest
The wiring of the nervous system arises from extensive directional migration of neuronal cell bodies and growth of processes that, somehow, end up forming functional circuits. Thus far, this feat ofExpand
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An improved mouse line for Cre‐induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus
The means to specifically ablate cells inside of a living organism have recently been improved and facilitated by stable mouse lines, carrying conditional expression constructs for diphtheria toxinExpand
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A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentiallyExpand
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