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Fragile X Mental Retardation Protein Regulates the Levels of Scaffold Proteins and Glutamate Receptors in Postsynaptic Densities*
The data suggest that dysregulation of Shank1 synthesis may significantly contribute to the abnormal spine development and function observed in brains of fragile X syndrome patients. Expand
Reverse physiology in Drosophila: identification of a novel allatostatin‐like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family
Picomolar concentrations of the synthesized octapeptide activated the cognate receptor response mediated through GIRK1, indicating that the authors have isolated the 394‐amino‐acid Drosophila allatostatin receptor which is coupled to the Gi/Go class of G proteins. Expand
Somatostatin Receptor Interacting Protein Defines a Novel Family of Multidomain Proteins Present in Human and Rodent Brain*
By using the yeast two-hybrid system we identified a novel protein from the human brain interacting with the C terminus of somatostatin receptor subtype 2. This protein termed somatostatin receptorExpand
RNA transport and local control of translation.
In eukaryotes, the entwined pathways of RNA transport and local translational regulation are key determinants in the spatio-temporal articulation of gene expression and recent data indicate that untranslated RNAs may play important roles in the local control of translation. Expand
Identification of a cis-Acting Dendritic Targeting Element in MAP2 mRNAs
The observation of RNA granules in dendrites implies that extrasomatic transcripts seem to assemble into multimolecular complexes that may function as transport units in hippocampal and sympathetic neurons. Expand
Postsynaptic Shank Antagonizes Dendrite Branching Induced by the Leucine-Rich Repeat Protein Densin-180
The data suggest a mechanism where shank could block the activation of a Densin-180-dependent signaling pathway by δ-catenin, which has been shown to induce branching and neurite formation. Expand
The Insulin Receptor Substrate IRSp53 Links Postsynaptic shank1 to the Small G-Protein cdc42
IRSp53 constitutes a cdc42-regulated ligand for shank1 which may provide a molecular basis for small G-protein mediated effects on the structure of the postsynaptic complex. Expand
Functional Annotation of Two Orphan G-protein-coupled Receptors, Drostar1 and -2, from Drosophila melanogaster and Their Ligands by Reverse Pharmacology*
Localization of receptor transcripts identifies a role of the new transmitter system in visual information processing as well as endocrine regulation and affects ligand binding, as previously described for somatostatin receptors. Expand
Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin‐like receptor 1 (SLC‐1)
Xenopus oocytes expressing the MCH receptor responded to nM concentrations of synthetic MCH not only by the activation of GIRK‐mediated currents but also by the induction of Ca2+ dependent chloride currents mediated by phospholipase C, indicating that the M CH receptor can couple either to the Gi‐ or Gq‐mediated signal transduction pathway, suggesting that MCH may serve for a number of distinct brain functions including food uptake behavior. Expand
Differential expression and dendritic transcript localization of Shank family members: identification of a dendritic targeting element in the 3′ untranslated region of Shank1 mRNA
The widespread presence of Shank mRNAs in dendrites suggests a role for local synthesis of Shanks in response to stimuli that induce alterations in synaptic morphology. Expand