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Assessing the quality of reports of randomized clinical trials: is blinding necessary?
An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described. Expand
Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review
The cannabinoids tested in these trials may be useful as mood enhancing adjuvants for controlling chemotherapy related sickness and potentially serious adverse effects, even when taken short term orally or intramuscularly are likely to limit their widespread use. Expand
Efficacy, Dose‐Response, and Safety of Ondansetron in Prevention of Postoperative Nausea and Vomiting: A Quantitative Systematic Review of Randomized Placebo‐controlled Trials
If the risk of PONV is very high, for every 100 patients receiving an adequate dose of ondansetron 20 patients will not vomit and three will have a headache who would not have had these adverse effects without the drug. Expand
Impact of covert duplicate publication on meta-analysis: a case study
There is no evidence of the impact of duplicate data on meta-analysis, and 17% of systematically searched randomised trials of ondansetron as a postoperative antiemetic were covert duplicates and resulted in 28% of patient data being duplicated. Expand
Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review
Cannabinoids are no more effective than codeine in controlling pain and have depressant effects on the central nervous system that limit their use, and in acute postoperative pain they should not be used. Expand
Cisplatin-evoked induction of c-fos protein in the brainstem of the ferret: the effect of cervical vagotomy and the anti-emetic 5-HT3 receptor antagonist granisetron (BRL 43694)
The results suggest that cisplatin induces c-fos gene expression in the nucleus of the solitary tract by an action involving vagal afferent pathways and also by a vagally independent, direct action on the area postrema. Expand
Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use
The number‐needed‐to‐treat for one patient to die due to gastroduodenal complications with chronic usage of non‐steroidal anti‐inflammatory drugs (NSAIDs) is calculated as 1/((0.69×{6–16%, average 12%})−0.002%))=909–2500 (average 1220). Expand
Substituted cyclic imides as potential anti-gout agents.
N-substituted cyclic imides of phthalimide, 2,3-dihydrohalazine-1,4-dione, and diphenimide were shown to reduce the serum uric acid levels in normal and hyperuric mice at 20 mg/kg/day I.P. for 14Expand
The epidemiology of carcinoid tumours in England and Scotland.
There was a consistent female excess of carcinoid tumours in the reproductive years, which was reversed after the age of 50, and there is some evidence to suggest a true sex difference in incidence, particularly the fact that the sex ratio for thoracic tumours varies with age in a similar way to that for gastrointestinal tumours. Expand
Delay in presentation of patients with acute stroke to hospital in Oxford.
If acute therapies for stroke become available, GPs should be the primary targets for an educational initiative, and initial contact with the GP is a major determinant of delay. Expand