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T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1.
TLDR
The ability of T 30177 to inhibit both laboratory and clinical isolates of HIV-1 and the experimental data which suggest that T30177 represents a novel class of integrase inhibitors indicate that this compound is a viable candidate for evaluation as a therapeutic agent against HIV- 1 in humans. Expand
Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus
TLDR
It appears that although acyclic nucleoside phosphonates may not have as favourable a therapeutic index as drugs requiring the viral TK, they should be considered for the treatment of TK− VZV life-threatening infections that are resistant to theiral TK-dependent drugs. Expand
Activity of a Sulfated Polysaccharide Extracted from the Red Seaweed Aghardhiella Tenera against Human Immunodeficiency Virus and Other Enveloped Viruses
TLDR
GS represents a natural polysaccharide with broad-spectrum activity against a number of important viral pathogens and proved active not only against HIV-1 and HIV-2 but also against other enveloped viruses, i.e. herpes-, toga-, arena-, myxo- and rhabdoviruses. Expand
Labour market shortages in the European Union
This study, provided by Policy Department A to the Committee on Employment and Social Affairs, gives an overview of labour shortages, looking at their types and causes, their occurrence within theExpand
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.
TLDR
In addition to its activity against HIV-1 and HIV-2 cy topathicity, cosalane inhibited the cytopathic effects of herpes simplex virus-1, herpes simpleX virus-2, and human cytomegalovirus at concentrations that were well below the cytotoxic concentrations. Expand
Meningoradiculoneuritis due to acyclovir‐resistant varicella zoster virus in an acquired immune deficiency syndrome patient
TLDR
The case of meningora‐diculoneuritis in an AIDS patient, associated with the isolation in the cerebrospinal fluid of a thymidine kinase (TK)‐deficient, acyclovir (ACV)‐resistant strain of VZV, where the patient did not improve during PFA therapy and finally died. Expand
Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata.
The antiviral activity of polysaccharide fractions obtained from water extracts of the red seaweed Nothogenia fastigiata was investigated. Fraction F6, corresponding to a sulphated xylomannan, wasExpand
The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding.
TLDR
PCR experiments revealed that no viral DNA was formed following viral infection, thus confining the target(s) of action of the bicyclams to an early stage of HIV infection, and it is concluded that bicyclams block the entry of cell-bound virus. Expand
Cell type-specific anti-human immunodeficiency virus type 1 activity of the transactivation inhibitor Ro5-3335.
TLDR
The drug Ro5-3335 inhibits human immunodeficiency virus type 1 (HIV-1) gene expression at the transcriptional level through interference with Tat-mediated transactivation based on transactivation of a chimeric gene comprising the HIV-1 long terminal repeat promoter fused to the lacZ gene of Escherichia coli and transfected in a HeLa cell line expressing Tat. Expand
Meningoradiculoneuritis due to acyclovir-resistant varicella-zoster virus in a patient with AIDS.
TLDR
The case of an AIDS patient who developed meningoradiculoneuritis while on oral acyclovir given prophylactically at 400 mg twice daily for 8 months after several episodes of multidermatomal zoster is described. Expand
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