D. Reusch

Publications60
h-index21
Citations1,466
Highly Influential Citations39
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In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity
The importance and effect of Fc glycosylation of monoclonal antibodies with regard to biological activity is widely discussed and has been investigated in numerous studies. Fc glycosylation of… Expand
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Fc-galactosylation modulates antibody-dependent cellular cytotoxicity of therapeutic antibodies.
The therapeutic activity of monoclonal antibodies can involve immune cell mediated effector functions including antibody-dependent cellular cytotoxicity (ADCC), an activity that is modulated by the… Expand
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Fc glycans of therapeutic antibodies as critical quality attributes
Critical quality attributes (CQA) are physical, chemical, biological or microbiological properties or characteristics that must be within an appropriate limit, range or distribution to ensure the… Expand
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In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor.
The N-terminal, extracellular domain of the receptor for glucagon-like peptide 1 (GLP-1 receptor) was expressed at a high level in E. coli and isolated as inclusion bodies. Renaturation with… Expand
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Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry
ABSTRACT High-molecular weight aggregates such as antibody dimers and other side products derived from incorrect light or heavy chain association typically represent critical product-related… Expand
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Glycoforms of Immunoglobulin G Based Biopharmaceuticals Are Differentially Cleaved by Trypsin Due to the Glycoform Influence on Higher-Order Structure.
It has been reported that glycosylation can influence the proteolytic cleavage of proteins. A thorough investigation of this phenomenon was conducted for the serine protease trypsin, which is… Expand
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Functional assessment of antibody oxidation by native mass spectrometry
Oxidation of methionine (Met) residues is one of several chemical degradation pathways for recombinant IgG1 antibodies. Studies using several methodologies have indicated that Met oxidation in the… Expand
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Identification and Monitoring of Host Cell Proteins by Mass Spectrometry Combined with High Performance Immunochemistry Testing
Biotherapeutics are often produced in non-human host cells like Escherichia coli, yeast, and various mammalian cell lines. A major focus of any therapeutic protein purification process is to reduce… Expand
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Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions
The quality control testing of chemical degradations in the bio-pharmaceutical industry is currently under controversial debate. Here we have systematically applied in vitro and in vivo stress… Expand
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Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 1: Separation-based methods
Immunoglobulin G (IgG) crystallizable fragment (Fc) glycosylation is crucial for antibody effector functions, such as antibody-dependent cell-mediated cytotoxicity, and for their pharmacokinetic and… Expand
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