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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells and induces strong proliferation of mouse memory T cells. Expand
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.
A new heterodimeric cytokine termed IL-27 is described that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL- 12p35-related polypeptide and drives rapid clonal expansion of naive but not memory CD4(+) T cells. Expand
A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R1
A novel member of the hemopoietin receptor family is identified as a subunit of the receptor for IL-23, “IL-23R,” which pairs with IL-12Rβ1 to confer IL- 23 responsiveness on cells expressing both subunits. Expand
Interleukin-10-deficient mice develop chronic enterocolitis
The results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract. Expand
Requirement for IL-13 independently of IL-4 in experimental asthma.
Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma and selective neutralization of IL-13 ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction. Expand
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.
We have characterized the progressive stages of chronic intestinal inflammation that develops spontaneously in specific pathogen-free (SPF) mice with a targeted disruption in the IL-10 geneExpand
IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo.
The results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types. Expand
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.
This study shows that in these models, IL-23 is essential for manifestation of chronic intestinal inflammation, whereas IL-12 is not, and a critical target of IL- 23 is a unique subset of tissue-homing memory T cells, which are specifically activated by IL-21 to produce the proinflammatory mediators IL-17 and IL-6. Expand
Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice
It is concluded that resident enteric bacteria are necessary for the development of spontaneous colitis and immune system activation in IL-10-deficient mice. Expand
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.
Results show that IL-10 is a critical component of the host's natural defense against the development of pathologic responses to LPS although it is not responsible for LPS-induced tolerance. Expand