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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
TLDR
Light is shed on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility and within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. Expand
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
TLDR
Variants near genes involved in cholesterol synthesis, hydroxylation, and vitamin D transport affect vitamin D status, and genetic variation at these loci identifies individuals who have substantially raised risk of vitamin D insufficiency. Expand
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
TLDR
Seven new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 × 10−8) in an analysis of all 41,282 samples, and an additional 11 SNPs replicated at P < 0.05, suggesting that most represent genuine rhearatoid arthritisrisk alleles. Expand
Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy.
TLDR
The daily, but not cumulative, GC dose was found to be a strong predictor of vertebral fracture in patients receiving oral glucocorticoids, and postmenopausal women taking GCs, as compared with nonusers of GCs had considerably higher risks of fracture. Expand
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
TLDR
A large, direct genome-wide study of association between CNVs and eight common human diseases concludes that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis ofcommon human diseases. Expand
Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I α 1 gene
TLDR
A novel G→T polymorphism in a regulatory region of COLIA1 at a recognition site for the transcription factor Sp17 that is significantly related to bone mass and osteoporotic fracture is described. Expand
Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty
TLDR
Although menopausal status and hormone replacement therapy use dominate women's bone health, diet may influence early postmenopausal bone loss and fruit and vegetable intake may protect against premenopausal Bone mineral density loss. Expand
Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health?
TLDR
The BMD results confirm previous work (but at peripheral bone mass sites), and the findings associating bone resorption with dietary factors provide further evidence of a positive link between fruit and vegetable consumption and bone health. Expand
Efficacy and Safety of Daily Risedronate in the Treatment of Corticosteroid‐Induced Osteoporosis in Men and Women: A Randomized Trial
TLDR
It is concluded that risedronate increases BMD and potentially reduces the incidence of vertebral fractures in patients with corticosteroid‐induced osteoporosis and was well tolerated, had a good safety profile, and was not associated with gastrointestinal adverse events. Expand
Rheumatoid arthritis association at 6q23
TLDR
One SNP, rs6920220, was unequivocally replicated in a validation study, as described here, and maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-α–induced protein 3 (TNFAIP3). Expand
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