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Principal components analysis corrects for stratification in genome-wide association studies
TLDR
This work describes a method that enables explicit detection and correction of population stratification on a genome-wide scale and uses principal components analysis to explicitly model ancestry differences between cases and controls. Expand
Population Structure and Eigenanalysis
TLDR
An approach to studying population structure (principal components analysis) is discussed that was first applied to genetic data by Cavalli-Sforza and colleagues, and results from modern statistics are used to develop formal significance tests for population differentiation. Expand
A Draft Sequence of the Neandertal Genome
TLDR
The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other. Expand
Detecting recent positive selection in the human genome from haplotype structure
TLDR
A framework for detecting the genetic imprint of recent positive selection by analysing long-range haplotypes in human populations is introduced, and the core haplotypes carrying the proposed protective mutation stand out and show significant evidence of selection. Expand
Ancient Admixture in Human History
TLDR
A suite of methods for learning about population mixtures are presented, implemented in a software package called ADMIXTOOLS, that support formal tests for whether mixture occurred and make it possible to infer proportions and dates of mixture. Expand
Reconstructing Indian Population History
TLDR
It is predicted that there will be an excess of recessive diseases in India, which should be possible to screen and map genetically and is higher in traditionally upper caste and Indo-European speakers. Expand
Testing for ancient admixture between closely related populations.
TLDR
This paper presents a test for ancient admixture that exploits the asymmetry in the frequencies of the two nonconcordant gene trees in a three-population tree, and derives the analytic expectation of a test statistic, called the D statistic, which is sensitive to asymmetry under alternative demographic scenarios. Expand
Genetic history of an archaic hominin group from Denisova Cave in Siberia
TLDR
A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans. Expand
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
TLDR
This high-density SNP map provides a public resource for defining haplotype variation across the genome, and should help to identify biomedically important genes for diagnosis and therapy. Expand
Genetic signatures of strong recent positive selection at the lactase gene.
TLDR
It is estimated that strong selection occurred within the past 5,000-10,000 years, consistent with an advantage to lactase persistence in the setting of dairy farming; the signals of selection the authors observe are among the strongest yet seen for any gene in the genome. Expand
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