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The Molecular Basis of Individual Differences in Phenylthiocarbamide and Propylthiouracil Bitterness Perception
Individual psychogenomic pathways for bitter taste are mapped by testing people with a variety of psychophysical tasks and linking their individual perceptions of the compounds PTC and propylthiouracil to the in vitro responses of their TAS2R38 receptor variants. Expand
Food Intake, Water Intake, and Drinking Spout Side Preference of 28 Mouse Strains
There were large strain differences in all the measures collected, with at least a two-fold difference between strains with the lowest and the highest trait values. Expand
The genetics of phenylthiocarbamide perception.
The ability to taste the bitter compound phenylthiocarbamide (PTC) and related chemicals is bimodal, and all human populations tested to date contain some people who can and some people who cannotExpand
Major taste loss in carnivorous mammals
The sequenced entire coding region of Tas1r2 from 12 species in the order Carnivora provided strong support for the view that loss of taste receptor function in mammals is widespread and directly related to feeding specializations. Expand
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection.
Evidence that the bitter taste receptor T2R38 regulates the mucosal innate defense of the human upper airway is presented and that genetic variation contributes to individual differences in susceptibility to respiratory infection is suggested. Expand
Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake.
These results support taste genetic effects on alcohol intake, and PROP bitterness serves as a marker of these effects. Expand
Polymorphisms in the Taste Receptor Gene (Tas1r3) Region Are Associated with Saccharin Preference in 30 Mouse Strains
Data is presented for future studies directed to experimentally confirm the function of Tas1r3 sequence variants associated with saccharin preference and highlight some of the difficulties of identifying specific DNA sequence variants that underlie quantitative trait loci. Expand
Genetics of Human Taste Perception
Sweet and umami tastes, mediated by TAS1R receptors, are becoming well-characterized at the molecular genetic level, and these taste classes are now targets for linkage, positional cloning, and genetic association strategies. Expand
Genetic and Environmental Determinants of Bitter Perception and Sweet Preferences
The effects of race/ethnicity were the strongest determinants, thus suggesting that cultural forces and experience may override this genotype effect on sweet preferences, as well as a portion of individual differences in preferences for sweet flavors in children but not in adults. Expand
Positional cloning of the mouse saccharin preference (Sac) locus.
This study provides compelling evidence that Tas1r3 is equivalent to the Sac locus and that the T1R3 receptor responds to sweeteners. Expand