• Publications
  • Influence
High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides.
Abstract A rapid and sensitive high-performance liquid chromatography method for determination of nanomole levels of glutathione, glutathione disulfide, cysteine glutathione-mixed disulfide and 20Expand
  • 1,114
  • 22
High-performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives.
Publisher Summary High-performance liquid chromatography (HPLC) provides a rapid, sensitive, and reproducible means of separating and quantifying simultaneously a variety of sulfur-containing aminoExpand
  • 490
  • 20
Glutathione: toxicological implications.
  • D. Reed
  • Biology, Medicine
  • Annual review of pharmacology and toxicology
  • 1990
Glutathione as reduced glutathione (GSH) and as the disulfide (GSSG) is a unique peptide that continues to interest toxicologists-as reflected in the numerous symposia and reviews ( 1-6). ThisExpand
  • 749
  • 19
Status of the mitochondrial pool of glutathione in the isolated hepatocyte.
Using the selective membrane-solubilizing properties of digitonin and a rapid centrifugation method to separate cytoplasmic and mitochondrial components, the metabolic state of mitochondrialExpand
  • 390
  • 7
Glutathione depletion and susceptibility.
  • 243
  • 5
Glutathione redox cycle-driven recovery of reduced glutathione after oxidation by tertiary-butyl hydroperoxide in preimplantation mouse embryos.
The purpose of this study was to determine whether mouse embryos at the two-cell to blastocyst stage have the capacity to reduce glutathione disulfide (GSSG) and to elucidate the mechanism thatExpand
  • 54
  • 5
Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates.
  • J. Babson, D. Reed
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 28 July 1978
Abstract The specific inactivation of yeast glutathione reductase (GSSG-reductase) by 2-chloroethyl isocyanate and cyclohexyl isocyanate derived from their respective 2-chloroethyl nitrosoureas hasExpand
  • 183
  • 4
Involvement of the cystathionine pathway in the biosynthesis of glutathione by isolated rat hepatocytes.
The ability of l-methionine to support glutathione biosynthesis has been investigated in isolated rat hepatocytes under conditions of normal and depleted glutathione status. The addition ofExpand
  • 140
  • 4
Radical-induced inactivation of kidney Na+,K(+)-ATPase: sensitivity to membrane lipid peroxidation and the protective effect of vitamin E.
The Na+,K(+)-ATPase is a membrane-bound, sulfhydryl-containing protein whose activity is critical to maintenance of cell viability. The susceptibility of the enzyme to radical-induced membrane lipidExpand
  • 100
  • 4
Cellular recovery of glyceraldehyde-3-phosphate dehydrogenase activity and thiol status after exposure to hydroperoxides.
  • A. Brodie, D. Reed
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 1990
The activity of the thiol-dependent enzyme glyceraldehyde-3-phosphate dehydrogenase (GPD), in vertebrate cells, was modulated by a change in the intracellular thiol:disulfide redox status. Human lungExpand
  • 79
  • 4