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Adiponectin Induces A20 Expression in Adipose Tissue to Confer Metabolic Benefit
Obesity is a major risk factor for metabolic disease, with white adipose tissue (WAT) inflammation emerging as a key underlying pathology. We detail that mice lacking Reverbα exhibit enhanced fatExpand
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Glucocorticoids suppress macrophage migration inhibitory factor (MIF) expression in a cell-type-specific manner.
MIF is a potent proinflammatory cytokine involved in inflammatory arthritis. Glucocorticoids (GC) have been reported to induce secretion of MIF in rodent cells, and as MIF counteracts theExpand
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Hypoxia and glucocorticoid signaling converge to regulate macrophage migration inhibitory factor gene expression.
OBJECTIVE Macrophage migration inhibitory factor (MIF) is a proinflammatory mediator involved in the pathogenesis of rheumatoid arthritis. This study was undertaken to identify the MIF promoterExpand
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Effect of rapamycin and prednisolone in differentiated THP-1 and U937 cells.
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The circadian clock protein REVERBα inhibits pulmonary fibrosis development
Pulmonary inflammatory responses lie under circadian control; however the importance of circadian mechanisms in fibrosis is not understood. Here, we identify a striking change to these mechanismsExpand
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The human prolactin gene upstream promoter is regulated in lymphoid cells by activators of T-cells and by cAMP.
Prolactin (PRL) is produced in human thymocytes, T-cells and endometrium. In these extrapituitary tissues, PRL gene transcription is directed by an alternative upstream promoter, and it is thought toExpand
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Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus
Patients with systemic lupus erythematosus (SLE) have accelerated cardiovascular disease and dysfunctional endothelial repair mechanisms. Myeloid angiogenic cells (MACs), derived from circulatingExpand
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MNAR functionally interacts with both NH2- and COOH-terminal GR domains to modulate transactivation
Glucocorticoids are potent anti-inflammatory agents, acting through the glucocorticoid receptor (GR) to regulate target gene transcription. However, GR may also exert acute effects, includingExpand
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Role of vitamin D in endothelial repair mechanisms in systemic lupus erythematosus
Abstract Background Patients with systemic lupus erythematosus (SLE) have an increased prevalence of cardiovascular disease (CVD). Vitamin D deficiency is common in SLE and is an independent riskExpand
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