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Genetic studies of body mass index yield new insights for obesity biology
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study.
The trainability of VO(2max) is highly familial and includes a significant genetic component, and the most parsimonious models yielded a maximal heritability estimate of 47%.
Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?
Adverse responses to regular exercise in cardiovascular and diabetes risk factors occur and identifying the predictors of such unwarranted responses and how to prevent them will provide the foundation for personalized exercise prescription.
Familial resemblance for VO2max in the sedentary state: the HERITAGE family study.
The hypothesis of maternal inheritance, with the father's contribution being environmental, was found to fit the data with estimates of maternal heritability, potentially associated with mitochondrial inheritance, reaching about 30%.
Effects of exercise training on glucose homeostasis: the HERITAGE Family Study.
Although the effects of structured regular exercise were highly variable, there were improvements in virtually all i.v.GTT-derived variables, suggesting that regular exercise is required for sustained improvements in glucose homeostasis.
Role of ghrelin polymorphisms in obesity based on three different studies.
The preproghrelin Met72 carrier status seems to be protective against fat accumulation and associated metabolic comorbidities.
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
The nearly complete catalog of genetic variation in TOPMed studies provides unique opportunities for exploring the contributions of rare and non-coding sequence variants to phenotypic variation as well as resources and early insights from the sequence data.
Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study.
- J. Després, C. Couillard, C. Bouchard
- MedicineArteriosclerosis, thrombosis, and vascular…
- 1 August 2000
The results suggest that the higher plasma HDL cholesterol levels and the generally more cardioprotective plasma lipoprotein profile found in abdominally obese black versus white individuals are explained, at least to a certain extent, by a lower visceral AT deposition and a higher plasma LPL activity in black individuals.
The HERITAGE family study. Aims, design, and measurement protocol.
- C. Bouchard, A. Leon, D. Rao, J. Skinner, J. Wilmore, J. Gagnon
- MedicineMedicine and science in sports and exercise
- 1 May 1995
The HERITAGE family study will document the role of the genotype in the cardiovascular, metabolic, and hormonal responses to aerobic exercise training, including heritability studies and major gene effects, for each phenotype and its response to regular exercise.
Genetic covariation between neuroticism and the symptoms of anxiety and depression
The lack of evidence for dominance variance affecting neuroticism contrasts well with the detection of considerable genetical nonadditivity for extraversion in the same sample and reinforces the view that these two traits are not only statistically, but also genetically, quite independent.