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  • Influence
Extracellular matrix biology in the lung.
The lung and other organs are comprised of both cellular and extracellular compartments. Interaction of these components modulates physiological function at the organ, cellular, and subcellularExpand
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Expression of functional gap junctions in cultured pulmonary alveolar epithelial cells.
Recent observations suggest that cell-cell interactions may modulate the response of the alveolar epithelium to injury. Expression and function of gap junctions were thus evaluated in isolatedExpand
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Inhibition of gap junction communication in alveolar epithelial cells by 18alpha-glycyrrhetinic acid.
Cultured alveolar epithelial cells exhibit gap junction intercellular communication (GJIC) and express regulated levels of connexin (Cx) 43 mRNA and protein. Newly synthesized radiolabeled Cx43Expand
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Influence of the extracellular matrix on type 2 cell differentiation.
Growth and division of type II pulmonary epithelial cells are important components of the pathway by which the alveolar surface is repaired following several forms of lung injury. These processes,Expand
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Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease
In a number of species, partial pneumonectomy initiates hormonally regulated compensatory growth of the remaining lung lobes that restores normal mass, structure and function. Compensation isExpand
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Connexin expression by alveolar epithelial cells is regulated by extracellular matrix.
Extracellular matrix (ECM) proteins promote attachment, spreading, and differentiation of cultured alveolar type II epithelial cells. The present studies address the hypothesis that the ECM alsoExpand
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Measurement of the rate of protein synthesis and compartmentation of heart phenylalanine.
Calculation of rates of protein synthesis, based upon incorporation of [14C]phenylalanine into protein, depended upon use of the specific activity of phenylalanyl-tRNA. At a perfusate phenylalanineExpand
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Role of laminin in maintenance of type II pneumocyte morphology and function.
Loss of differentiated function by type II pneumocytes plated on plastic surfaces was demonstrated by decreased lamellar body content, increased cellular protein, and rapid cellular flattening,Expand
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Inhibition of protein degradation by anoxia and ischemia in perfused rat hearts.
Hypoxia and anoxia were induced in isolated perfused rat hearts by reduction of perfusate oxygen tension. Ischemia was produced by restricting coronary flow in hearts working against high resistance.Expand
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Role of physical forces in compensatory growth of the lung.
  • D. Rannels
  • Biology, Medicine
  • The American journal of physiology
  • 1 October 1989
In many species, partial resection of the lung leads to rapid compensatory growth of the remaining tissue to restore normal lung mass and function. The response to partial pneumonectomy is closelyExpand
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