• Publications
  • Influence
Lethargus is a Caenorhabditis elegans sleep-like state
TLDR
The association of this C. elegans sleep-like state with developmental changes that occur with larval moults suggests that sleep may have evolved to allow for developmental changes. Expand
Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans.
TLDR
It is proposed that eat-18 and eat-2 function in a multisubunit protein complex involved in the function of a pharyngeal nAChR, which acts as a neurogenic pacemaker for pharygeal pumping. Expand
Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety.
TLDR
It is proposed that quiescence results from satiety, and it is hypothesized that the EGL-4 cGMP-dependent protein kinase functions downstream of insulin and TGF-beta in sensory neurons including ASI to control quiescent in response to food intake. Expand
Cellular Stress Induces a Protective Sleep-like State in C. elegans
TLDR
Evidence is provided that cellular stress can induce a protective sleep-like state in C. elegans and suggest that a deeply conserved function of sleep is to mitigate disruptions of cellular homeostasis. Expand
eat-2 and eat-18 Are Required for Nicotinic Neurotransmission in the Caenorhabditis elegans Pharynx
TLDR
In eat-18 mutants, the gross localization of EAT-2 at the MC synapse is normal, suggesting that it is not required for trafficking, and data indicate that eat- 18 could be a novel component of the pharyngeal nicotinic receptor. Expand
Electrical activity and behavior in the pharynx of caenorhabditis elegans
TLDR
Using the electropharyngeograms, it is shown that gamma-aminobutyric acid is not likely to be the M3 neurotransmitter, that synaptic transmission is present but abnormal in mutants lacking synaptotagmin, and that worms mutant in the eat-4 gene are defective for M3 function or transmission. Expand
FMRFamide-like FLP-13 Neuropeptides Promote Quiescence following Heat Stress in Caenorhabditis elegans
TLDR
It is reported here that quiescence induced by heat stress requires ALA depolarization and release of FMRFamide-like neuropeptides encoded by the flp-13 gene, and it is suggested that they may function in a similar capacity in other organisms. Expand
Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging
TLDR
The WorMotel is described, a microfabricated device for long-term cultivation and automated longitudinal imaging of large numbers of C. elegans confined to individual wells that finds that short-lived and long-lived strains exhibit patterns of behavioral decline that do not temporally scale between individuals or populations, but rather resemble the shortest and longest lived individuals in a wild type population. Expand
Engineering adenylate cyclases regulated by near-infrared window light
TLDR
An adenylate cyclase is constructed, which can control cAMP-dependent processes in live animals in response to light in the near-infrared spectral window, and several light-activated fusion proteins that differed from each other by approximately one or two α-helical turns are engineered, suggesting that positioning of the output domains in the same phase of the helix is important for light-dependent activity. Expand
Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States
TLDR
This work uses optogenetic manipulations of neuronal and muscular activity, pharmacology, and genetic perturbations to uncover circuit and molecular mechanisms of DTQ and SIQ, and finds that locomotion quiescence induced by DTQ- andSIQ-associated neuropeptides occurs via their action on the nervous system, although their neuronal target(s) and/or molecular mechanisms likely differ. Expand
...
1
2
3
4
5
...