Antineoplastic efficacy of doxorubicin enzymatically assembled on galactose residues of a monoclonal antibody specific for the carcinoembryonic antigen.
- A. Stan, D. Radu, S. Casares, C. Bona, T. Brumeanu
- BiologyCancer Research
Enzymatically mediated, glycosidic coupling of antineoplastic agents to antibodies specific for tumor-associated antigens may represent a novel platform for the development of more efficient anticancer agents with reduced side effects.
Disruption of intracerebral progression of C6 rat glioblastoma by in vivo treatment with anti-CD44 monoclonal antibody.
- R. Breyer, S. Hussein, A. Stan
- BiologyJournal of Neurosurgery
It is concluded that CD44s-targeted treatment with specific mAb may represent an effective means for preventing progression of highly invasive GBMs.
Double transgenic mice with Type 1 diabetes mellitus develop somatic, metabolic and vascular disorders
- D. Radu, A. Georgescu, C. Stăvaru, Alina Carale, D. Popov
- Biology, MedicineJournal of Cellular and Molecular Medicine
- 1 July 2004
It is shown that dTg mice developed type 1 diabetes mellitus associated with hyperglycemia, low level of plasma insulin, glucosuria, weight loss and ∼ 90% mortality (at 3 months biological age).
COX-2 inhibitors can down-regulate in vivo antibody response against T-dependent antigens.
It is confirmed that it is possible to modulate in vivo antibody response against T cell dependent antigens, substantiating the importance of PGE2 and E prostanoid receptor (EP-R) in antibody generation.
Doxorubicin-induced cell death in highly invasive human gliomas.
- A. Stan, S. Casares, D. Radu, G. F. Walter, T. Brumeanu
- Biology, MedicineAnticancer Research
- 1 March 1999
It is suggested that highly invasive glioblastomas can be driven to apoptosis following growth arrest induced by Doxorubicin, providing that intracellular drug accumulation suffices cytotoxic levels.
CD44s-targeted treatment with monoclonal antibody blocks intracerebral invasion and growth of 9L gliosarcoma
- S. Gunia, S. Hussein, A. Stan
- BiologyClinical and Experimental Metastasis
- 1 May 1999
CD44s-targeted treatment with specific mAb may be an effective means for preventing glioma progression, thus blocking growth of the 9L gliosarcoma in vivo.
A targeted mutation in the IL-4Ralpha gene protects mice against autoimmune diabetes.
- D. Radu, N. Noben-Trauth, J. Hu‐Li, W. Paul, C. Bona
- Biology, MedicineProceedings of the National Academy of Sciences…
- 7 November 2000
The inability to respond to IL-4 and/or IL-13 protects mice against IDDM in this model of autoimmunity.
Molecular analysis of the first avian influenza H5N1 isolates from fowl in Romania.
- G. Oprișan, H. Coste, M. Popa
- BiologyRoumanian archives of microbiology and immunology
- 1 July 2006
The virological and molecular analysis of the first strains of avian virus from Romania confirmed the presence of H5N1 subtype, belonging to the genetic line Z, and indicate that the avianirus from this genetic line is directly derived from the highly pathogenic viruses isolated in China and Russia in 2005.
Molecular studies on the diversification of hemagglutinin-specific human neonatal repertoire subsequent to immunization with naked DNA.
Evidence for immune defects in breast and lung cancer patients
- I. Caras, A. Grigorescu, A. Salageanu
- Biology, MedicineCancer Immunology and Immunotherapy
- 4 June 2004
The results showed that both peripheral T lymphocytes and NK cells of cancer patients could be induced to express early activation marker CD69 after ex vivo mitogen stimulation, and suggests that an appropriate immunotherapeutical approach might be used to restore compromised immune functions with beneficial effects on both antitumor and general immunity.