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Association of poliovirus proteins with the endoplasmic reticulum.
Poliovirus proteins, except P3-7c, are associated with the endoplasmic reticulum after extraction of the cytoplasm and centrifugation of membranes to equilibrium in sucrose gradients. Proteins P3-2,Expand
Guanidine-resistant mutants of poliovirus have distinct mutations in peptide 2C.
In previous work in our laboratory, 12 guanidine-resistant (gr) mutants of poliovirus were selected from 12 separate stocks of plaque-purified guanidine-sensitive (gs) viruses (K. Anderson-Sillman,Expand
Inhibition of poliovirus polymerase by guanidine in vitro.
Extracts from poliovirus-infected HeLa cells synthesized 35s viral RNA, replicative intermediate, and double-stranded RNA in vitro. Guanidine inhibited the synthesis of all three species of RNA;Expand
Guanidine-resistant defective interfering particles of poliovirus.
A mixture containing standard poliovirus and D3 particles (mutants with deletions in the capsid locus) was serially passaged in the presence of guanidine. Within five growth cycles, the standardExpand
Effect of temperature on the cleavage of polypeptides during growth of LSc poliovirus.
Abstract At 35 °C poliovirus induces the synthesis of at least 12 peptides with molecular weights ranging from 125,000 to 18,000 daltons as estimated by polyacrylamide gel electrophoresis. At 39 °CExpand
Effects of 5-fluorouracil and 6-azauridine on interferon action.
During the past few years, several laboratories reported that actinomycin D blocked the antiviral activity of interferon (E. Heller, Virology 21:652, 1963; J. Taylor, Biochem. Biophys. Res. Commun.Expand
Guanidine-resistant poliovirus mutants produce modified 37-kilodalton proteins.
Eighteen spontaneous, guanidine-resistant mutants of poliovirus were obtained by plaque selection. Isoelectric focusing demonstrated charge changes in a 37-kilodalton protein, pX, among three of theExpand
Effect of 5-fluorouracil on poliovirus-induced RNA polymerase.
  • D. R. Tershak
  • Biology, Medicine
  • Journal of molecular biology
  • 28 October 1966
HeLa cells were infected with type 1 poliovirus in drug-free medium and in medium containing 1.2 × 10−3 m-5-fluorouracil during the first 2.5 hours of virus growth. Extracts of poliovirus polymeraseExpand
EFFECT OF 5-FLUOROURACIL ON POLIOVIRUS GROWTH.
Abstract Poliovirus grown in the presence of 8.5 × 10 −2 M 5-fluorouracil (FU-virus) was twice as sensitive to UV light as virus propagated in the absence of drug. Growth curves of control andExpand
A STUDY OF PROTEIN SYNTHESIZED DURING THE ECLIPSE PHASE OF POLIOVIRUS GROWTH: AN ULTRAVIOLET LIGHT AND PUROMYCIN ANALYSIS.
Poliovirus-infected cells registered as infectious centers when plated on monkey kidney monolayer cultures under agar overlay. The sensitivity of infectious centers to ultraviolet light decreasedExpand
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