D. R. Spring

Publications385
h-index49
Citations10,862
Highly Influential Citations125
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Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways.
Numerous species of bacteria employ a mechanism of intercellular communication known as quorum sensing. This signaling process allows the cells comprising a bacterial colony to coordinate their gene… Expand
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The molecular basis of the host response to lipopolysaccharide
Lipopolysaccharide (LPS), which is produced by Gram-negative bacteria, is a powerful activator of innate immune responses. LPS binds to the proteins Toll-like receptor 4 (TLR4) and MD2 to activate… Expand
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Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips.
The TOR (target of rapamycin) proteins play important roles in nutrient signaling in eukaryotic cells. Rapamycin treatment induces a state reminiscent of the nutrient starvation response, often… Expand
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Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site
Summary The maintenance of genomic stability relies on the spindle assembly checkpoint (SAC), which ensures accurate chromosome segregation by delaying the onset of anaphase until all chromosomes are… Expand
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Chemical Genetics to Chemical Genomics: Small Molecules Offer Big Insights
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Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorum-sensing capacities.
Serratia marcescens is an important cause of opportunistic human infections. Many, but not all, strains produce prodigiosin, a secondary metabolic, red-pigment antibiotic, the biosynthesis of which… Expand
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Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria.
Quorum sensing is a form of intercellular communication used by many species of bacteria that facilitates concerted interactions between the cells comprising a population. The phenotypes regulated by… Expand
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Which microbial factors really are important in Pseudomonas aeruginosa infections?
Over the last two decades, tens of millions of dollars have been invested in understanding virulence in the human pathogen, Pseudomonas aeruginosa. However, the top 'hits' obtained in a recent TnSeq… Expand
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Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules.
Many Gram-negative bacteria use quorum sensing (QS) to regulate expression of multiple genes, by utilizing small diffusible signalling molecules called N-acyl homoserine lactones (acyl-HSLs).… Expand
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Peptide stapling techniques based on different macrocyclisation chemistries.
Peptide stapling is a strategy for constraining short peptides typically in an alpha-helical conformation. Stapling is carried out by covalently linking the side-chains of two amino acids, thereby… Expand
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