Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways.
- W. R. Galloway, J. Hodgkinson, Steven D. Bowden, M. Welch, D. R. Spring
- Chemistry, Medicine
- Chemical reviews
- 12 January 2011
Numerous species of bacteria employ a mechanism of intercellular communication known as quorum sensing. This signaling process allows the cells comprising a bacterial colony to coordinate their gene… Expand
The molecular basis of the host response to lipopolysaccharide
- C. Bryant, D. R. Spring, M. Gangloff, N. Gay
- Biology, Medicine
- Nature Reviews Microbiology
- 2010
Lipopolysaccharide (LPS), which is produced by Gram-negative bacteria, is a powerful activator of innate immune responses. LPS binds to the proteins Toll-like receptor 4 (TLR4) and MD2 to activate… Expand
Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips.
- Jing Huang, H. Zhu, +5 authors S. Schreiber
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 23 November 2004
The TOR (target of rapamycin) proteins play important roles in nutrient signaling in eukaryotic cells. Rapamycin treatment induces a state reminiscent of the nutrient starvation response, often… Expand
Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site
- V. Bolanos-Garcia, Tiziana Lischetti, +7 authors T. Blundell
- Biology, Medicine
- Structure
- 9 November 2011
Summary The maintenance of genomic stability relies on the spindle assembly checkpoint (SAC), which ensures accurate chromosome segregation by delaying the onset of anaphase until all chromosomes are… Expand
Chemical Genetics to Chemical Genomics: Small Molecules Offer Big Insights
- D. R. Spring
- Chemistry
- 27 September 2005
Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorum-sensing capacities.
- S. Coulthurst, N. Williamson, A. K. Harris, D. R. Spring, G. Salmond
- Biology, Medicine
- Microbiology
- 1 July 2006
Serratia marcescens is an important cause of opportunistic human infections. Many, but not all, strains produce prodigiosin, a secondary metabolic, red-pigment antibiotic, the biosynthesis of which… Expand
Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria.
- W. R. Galloway, J. Hodgkinson, Steven D. Bowden, M. Welch, D. R. Spring
- Biology, Medicine
- Trends in microbiology
- 1 September 2012
Quorum sensing is a form of intercellular communication used by many species of bacteria that facilitates concerted interactions between the cells comprising a population. The phenotypes regulated by… Expand
Which microbial factors really are important in Pseudomonas aeruginosa infections?
- A. Crousilles, E. Maunders, +7 authors M. Welch
- Biology, Medicine
- Future microbiology
- 30 October 2015
Over the last two decades, tens of millions of dollars have been invested in understanding virulence in the human pathogen, Pseudomonas aeruginosa. However, the top 'hits' obtained in a recent TnSeq… Expand
Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules.
- Simon Poulter, Timothy M. Carlton, Xianbin Su, D. R. Spring, G. Salmond
- Biology, Medicine
- Environmental microbiology reports
- 1 April 2010
Many Gram-negative bacteria use quorum sensing (QS) to regulate expression of multiple genes, by utilizing small diffusible signalling molecules called N-acyl homoserine lactones (acyl-HSLs).… Expand
Peptide stapling techniques based on different macrocyclisation chemistries.
- Y. H. Lau, Peterson de Andrade, Y. Wu, D. R. Spring
- Chemistry, Medicine
- Chemical Society reviews
- 7 January 2015
Peptide stapling is a strategy for constraining short peptides typically in an alpha-helical conformation. Stapling is carried out by covalently linking the side-chains of two amino acids, thereby… Expand
...
1
2
3
4
5
...