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Domino Ring Expansion: Regioselective Access to 9-Membered Lactones with a Fused Indole Unit from 2-Nitrophenyl-1,3-cyclohexanediones.
TLDR
The domino anionic fragmentation of 2-nitrophenyl-1,3-cyclohexanediones containing an electrophilic appendage such as aldehyde and epoxide is disclosed and provides an original access to decorated 9-membered lactones with a fused indole unit. Expand
Nucleophilic-Addition-Initiated Ring Expansion and Selectivity in Anionic Fragmentation.
The expansion of rings into larger ones by a mechanism of anionic fragmentation is a potent tool for exploring new structural space in a concise manner. As the concept has been known and applied forExpand
Study toward an Asymmetric and Catalytic Synthesis of Koumine
A synthetic study of koumine, a natural product with a densely functionalized and inspiring heterocyclic skeleton, was conducted by exploring a strategy of desymmetrization of 1,3-cyclohexanedione byExpand
The Spiritual Roots of Civil Society
English and American civil society has spiritual origins, and those origins survive today as roots still necessary for its nourishment. We cannot understand the historical development of civilExpand