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High-titre, cryostable cell-free varicella zoster virus
SummaryWork with varicella-zoster virus has been seriously hampered by the difficulty of preparing high-titre cell free virus, and by the instability of such virus when frozen and thawed. We haveExpand
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The role of regulated clinical trials in the development of bacteriophage therapeutics
Antibiotic resistance is now recognized as a major, global threat to human health and the need for the development of novel antibacterial therapies has become urgent. Lytic bacteriophages (phages)Expand
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Bacteriophage applications: where are we now?
Bacteriophages are bacterial viruses and have been used for almost a century as antimicrobial agents. In the West, their use diminished when chemical antibiotics were introduced, but they remain aExpand
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Identification of immunodominant regions and linear B cell epitopes of the gE envelope protein of varicella-zoster virus.
The envelope proteins of varicella-zoster virus (VZV) are highly immunogenic and one of the most abundant is glycoprotein E (gE). However, its immunodominant regions and epitopes have not beenExpand
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Phage therapy: delivering on the promise.
Bacteriophages are viruses that infect and, in many cases, destroy their bacterial targets. Within a few years of their initial discovery they were being investigated as therapeutic agents forExpand
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Nucleic acid immunization: concepts and techniques associated with third generation vaccines.
A radical change in vaccine methodology arrived nine years ago with the advent of nucleic acid immunization. Aspects such as plasmid design, gene selection, the use of immunostimulatory complexes andExpand
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Inhibition of varicella-zoster virus replication by an inhibitor of protein myristoylation.
Inhibitors of myristoylation and analogues of myristic acid inhibit the replication of some retroviruses including human immunodeficiency virus, but no studies with other virus families have beenExpand
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Bacteriophage therapy: potential uses in the control of antibiotic-resistant pathogens
The use of bacteriophages (phages) to treat bacterial infections, known as phage therapy, has a history substantially longer than that of antibiotics, yet these drugs have been the treatment ofExpand
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Protein blotting: ten years on.
Protein blotting was originally described in 1979 as an outgrowth of nucleic acid techniques, and received its commonly used designation of 'Western' blotting in 1981. The use of the technique toExpand
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Induction of neutralizing antibody and T-cell responses to varicella-zoster virus (VZV) using Ty-virus-like particles carrying fragments of glycoprotein E (gE).
During infection with Varicella-zoster virus (VZV), the envelope proteins are highly immunogenic and glycoprotein E (gE) is one of the most abundant and antigenic. We have previously identified theExpand
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