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Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors.
Aging affects every innate immune cell, including changes in cell numbers and function. Defects in the function of some cells are intrinsic, whereas for other cells, defects are extrinsic andExpand
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The Role of Hyaluronan Degradation Products as Innate Alloimmune Agonists
Dendritic cells (DCs) play a key role in initiating alloimmunity yet the substances that activate them during the host response to transplantation remain elusive. In this study we examined theExpand
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Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host.
Infection with Plasmodium berghei ANKA is a well-established model of human cerebral malaria (CM). We show herein that Toll-like receptor (TLR) signaling influences the development of lethal CM in P.Expand
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Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection.
Morbidity and mortality associated with viral infections increase with age, although the underlying mechanisms are unclear. Here, we investigated whether aging alters inflammatory responses duringExpand
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An essential role for Fas ligand in transplantation tolerance induced by donor bone marrow
Medawar and co-workers originally demonstrated that injection of donor bone marrow (DBM) into immuno-incompetent neonatal rodents could induce tolerance to grafts from animals of the same strain asExpand
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Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality
Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection; however, whether this is due to impaired viralExpand
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Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly
Increasing age alters innate immune–mediated responses; however, the mechanisms underpinning these changes in humans are not fully understood. Using a human dermal model of acute inflammation, weExpand
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Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19
Aging impairs immunity to promote diseases, especially respiratory viral infections. The current COVID-19 pandemic, resulting from SARS-CoV-2, induces acute pneumonia, a phenotype that is alarminglyExpand
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Influenza virus inoculum volume is critical to elucidate age‐dependent mortality in mice
The elderly exhibit increased mortality to influenza viral infection for unclear reasons. Mice are frequently used to model how aging impacts disease. Several studies have shown that aged miceExpand
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Role of Toll-like receptors in transplantation tolerance
Solid organ transplantation is a valuable therapeutic modality for a variety of end-organ diseases. The success of this therapy is largely a consequence of the development of modern immunosuppressiveExpand
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